Deuterated phospholipids to study the structure, function and dynamics of membrane proteins using neutron scattering

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dc.contributor.authorYepuri, NRen_AU
dc.contributor.authorMoir, Men_AU
dc.contributor.authorKrause-Heuer, AMen_AU
dc.contributor.authorDarwish, TAen_AU
dc.date.accessioned2023-09-25T02:46:09Zen_AU
dc.date.available2023-09-25T02:46:09Zen_AU
dc.date.issued2021-11-26en_AU
dc.date.statistics2023-04-24en_AU
dc.descriptionCitation shows N. R Yepuri as R. Yepuri.en_AU
dc.description.abstractContrast matching and contrast variation in neutron scattering provide unparalleled power for understanding the structure, function, and dynamics of a selected component in a multicomponent system. A sophisticated contrast study often requires the availability of deuterated molecules in which deuterium atoms are introduced in a predictable and controlled fashion to replace protons. This can be achieved by direct deuteration of precursors followed by custom chemical synthesis, for which expertise and capabilities have been developed at facility (NDF), ANSTO. It this paper we will discuss recent high impact research output using deuterated phospholipids produced by NDF/ANSTO. We will describe the synthesis and applications of selectively or perdeuterated unsaturated phospholipids to contrast match out the whole lipid bilayer or nano disks within a multicomponent system. Further, we also describe their role in investigations related to membrane lipoproteins (ApoE) exchange in relation to lipid unsaturation,[1] effect of membrane composition,[2] and conformational analysis Mg+2 channel by neutron scattering techniques.[2, 3]en_AU
dc.identifier.articlenumber91en_AU
dc.identifier.citationYepuri, R., Moir, M, Krause-Heuer, A., & Darwish, T. (2021). Deuterated phospholipids to study the structure, function and dynamics of membrane proteins using neutron scattering. Presentation to the ANSTO User Meeting, Online, 24-26 November 2021. Retrieved from: https://events01.synchrotron.org.au/event/146/contributions/4290/contribution.pdfen_AU
dc.identifier.conferenceenddate2021-11-26en_AU
dc.identifier.conferencenameANSTO User Meeting 2021en_AU
dc.identifier.conferenceplaceOnlineen_AU
dc.identifier.conferencestartdate2021-11-24en_AU
dc.identifier.urihttps://events01.synchrotron.org.au/event/146/contributions/4290/contribution.pdfen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15128en_AU
dc.language.isoenen_AU
dc.publisherAustralian Nuclear Science and Technology Organisationen_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/146/contributions/4290/contribution.pdfen_AU
dc.subjectDeuterationen_AU
dc.subjectPhospholipidsen_AU
dc.subjectMembranesen_AU
dc.subjectScatteringen_AU
dc.subjectMoleculesen_AU
dc.subjectProtonsen_AU
dc.subjectSynthesisen_AU
dc.subjectDeuteriumen_AU
dc.titleDeuterated phospholipids to study the structure, function and dynamics of membrane proteins using neutron scatteringen_AU
dc.typeConference Presentationen_AU
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