Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy

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dc.contributor.authorChacon, Aen_AU
dc.contributor.authorGuatelli, Sen_AU
dc.contributor.authorRutherford, Hen_AU
dc.contributor.authorBolst, Den_AU
dc.contributor.authorMohammadi, Aen_AU
dc.contributor.authorAhmed, Aen_AU
dc.contributor.authorNitta, Men_AU
dc.contributor.authorNishikido, Fen_AU
dc.contributor.authorIwao, Yen_AU
dc.contributor.authorTashima, Hen_AU
dc.contributor.authorYoshida, Een_AU
dc.contributor.authorAkamatsu, Gen_AU
dc.contributor.authorTakyu, Sen_AU
dc.contributor.authorKitagawa, Aen_AU
dc.contributor.authorHofmann, Ten_AU
dc.contributor.authorPinto, Men_AU
dc.contributor.authorFranklin, DRen_AU
dc.contributor.authorParodi, Ken_AU
dc.contributor.authorYamaya, Ten_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.contributor.authorSafavi-Naeini, Men_AU
dc.date.accessioned2025-01-16T04:55:26Zen_AU
dc.date.available2025-01-16T04:55:26Zen_AU
dc.date.issued2019-08-01en_AU
dc.date.statistics2024-10-16en_AU
dc.description.abstractThe distribution of fragmentation products predicted by Monte Carlo simulations of heavy ion therapy depend on the hadronic physics model chosen in the simulation. This work aims to evaluate three alternative hadronic inelastic fragmentation physics options available in the Geant4 Monte Carlo radiation physics simulation framework to determine which model most accurately predicts the production of positron-emitting fragmentation products observable using in-beam PET imaging. Fragment distributions obtained with the BIC, QMD, and INCL + + physics models in Geant4 version 10.2.p03 are compared to experimental data obtained at the HIMAC heavy-ion treatment facility at NIRS in Chiba, Japan. For both simulations and experiments, monoenergetic beams are applied to three different block phantoms composed of gelatin, poly(methyl methacrylate) and polyethylene. The yields of the positron-emitting nuclei 11C, 10C and 15O obtained from simulations conducted with each model are compared to the experimental yields estimated by fitting a multi-exponential radioactive decay model to dynamic PET images using the normalised mean square error metric in the entrance, build up/Bragg peak and tail regions. Significant differences in positron-emitting fragment yield are observed among the three physics models with the best overall fit to experimental 12C and 16O beam measurements obtained with the BIC physics model. © 2019 Commonwealth of Australia, Australian Nuclear Science and Technology Organisation, ANSTO.en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber155014en_AU
dc.identifier.citationChacon, A., Guatelli, S., Rutherford, H., Bolst, D., Mohammadi, A., Ahmed, A., Nitta, M., Nishikido, F., Iwao, Y., Tashima, H., Yoshida, E., Akamatsu, G., Takyu, S., Kitagawa, A., Hofmann, T., Pinto, M., Franklin, D. R., Parodi, K., Yamaya, T., Rosenfeld, A., & Safavi-Naeini, M. (2019). Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy. Physics in Medicine & Biology, 64(15), 155014. doi.org/10.1088/1361-6560/ab2752en_AU
dc.identifier.issn0031-9155en_AU
dc.identifier.issn1361-6560en_AU
dc.identifier.issue15en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.urihttps://doi.org/10.1088/1361-6560/ab2752en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15948en_AU
dc.identifier.volume64en_AU
dc.languageengen_AU
dc.language.isoenen_AU
dc.publisherIOP Publishingen_AU
dc.subjectIonsen_AU
dc.subjectPositronsen_AU
dc.subjectCarbonen_AU
dc.subjectOxygenen_AU
dc.subjectProductionen_AU
dc.subjectTherapyen_AU
dc.subjectFragmentationen_AU
dc.subjectMonte Carlo Methoden_AU
dc.subjectSimulationen_AU
dc.subjectPhysicsen_AU
dc.titleComparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapyen_AU
dc.typeJournal Articleen_AU
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