Incorporating clinical imaging into the delivery of microbeam radiation therapy

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dc.contributor.authorPaino, JRen_AU
dc.contributor.authorBarnes, Men_AU
dc.contributor.authorEngels, Een_AU
dc.contributor.authorDavis, JAen_AU
dc.contributor.authorGuatelli, Sen_AU
dc.contributor.authorde Veer, Men_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorTehei, Men_AU
dc.contributor.authorCorde, Sen_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.contributor.authorLerch, MLFen_AU
dc.date.accessioned2024-12-19T04:20:37Zen_AU
dc.date.available2024-12-19T04:20:37Zen_AU
dc.date.issued2021-09-30en_AU
dc.date.statistics2024-12-18en_AU
dc.description.abstractSynchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours. The protocol utilises existing infrastructure available at the Australian Synchrotron and the adjoining Monash Biomedical Imaging facility. The protocol is designed and optimised to treat small animals utilising high-resolution clinical CT for patient specific tumour identification, coupled with conventional radiography, using the recently developed SyncMRT program for image guidance. Dosimetry performed in small animal phantoms shows patient dose is comparable to standard clinical doses, with a CT associated dose of less than 1.39cGy and a planar radiograh dose of less than 0.03cGy. Experimental validation of alignment accuracy with radiographic film demonstrates end to end accuracy of less than ±0.34mm in anatomical phantoms. Histological analysis of tumour-bearing rats treated with microbeam radiation therapy verifies that tumours are targeted well within applied treatment margins. To date, this technique has been used to treat 35 tumour-bearing rats. © 2021 by the Authors. Licensee MDPI, Basel, Switzerland.en_AU
dc.description.sponsorshipThis research was supported by an Australian Government Research Training Program Scholarship and the Australian National Health & Medical Research Council (APP1084994 and APP1093256). This research was undertaken on the Imaging and Medical beamline at the Australian Synchrotron, part of ANSTO (IMBL/13777;14127;15023) The authors acknowledge the facilities and scientific and technical assistance of the National Imaging Facility (NIF), a National Collaborative Research Infrastructure Strategy (NCRIS) capability at Monash Biomedical Imaging (MBI), a Technology Research Platform at Monash University; the Illawarra Health and Medical Research Institute (IHMRI), Wollongong, Australia; the Australian Synchrotron, Melbourne, Australia; the Australian Nuclear Science and Technology Organisation; and the University of Wollongong (UOW) Animal House. We are grateful to Malcolm France for their assistance with histological analysis, and to all assisting personnel including IMBL staff, Beamline Veterinary Scientist Mitzi Klein, MBI Preclinical Facility Scientist Tara Sepehrizadeh, UOW animal research staff, and UOW Animal Welfare Officer Sarah Toole. We acknowledge the support of the Australian Nuclear Science and Technology Organisation Australian Synchrotron and UOW Animal Ethics Committees.en_AU
dc.identifier.articlenumber9101en_AU
dc.identifier.citationPaino, J., Barnes, M., Engels, E., Davis, J., Guatelli, S., de Veer, M., Hall, C., Häusermann, D., Tehei, M., Corde, S., Rosenfeld, A., & Lerch, M. (2021). Incorporating clinical imaging into the delivery of microbeam radiation therapy. Applied Sciences, 11(19), 9101. doi:10.3390/app11199101en_AU
dc.identifier.issn2076-3417en_AU
dc.identifier.issue19en_AU
dc.identifier.journaltitleApplied Sciencesen_AU
dc.identifier.urihttps://doi.org/10.3390/app11199101en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15837en_AU
dc.identifier.volume11en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherMDPIen_AU
dc.subjectImagesen_AU
dc.subjectRadiotherapyen_AU
dc.subjectDosimetryen_AU
dc.subjectSynchrotronsen_AU
dc.subjectAustraliaen_AU
dc.subjectBiomedical radiographyen_AU
dc.titleIncorporating clinical imaging into the delivery of microbeam radiation therapyen_AU
dc.typeJournal Articleen_AU
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