Unexpectedly enhanced solubility of aromatic amino acids and peptides in an aqueous solution of divalent transition-metal cations

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dc.contributor.authorShi, GSen_AU
dc.contributor.authorDang, Yen_AU
dc.contributor.authorPan, TTen_AU
dc.contributor.authorLiu, Xen_AU
dc.contributor.authorLiu, Hen_AU
dc.contributor.authorLi, Sen_AU
dc.contributor.authorZhang, LJen_AU
dc.contributor.authorZhao, HWen_AU
dc.contributor.authorLi, SPen_AU
dc.contributor.authorHan, JGen_AU
dc.contributor.authorTai, RZen_AU
dc.contributor.authorZhu, Yen_AU
dc.contributor.authorLi, Jen_AU
dc.contributor.authorJi, Qen_AU
dc.contributor.authorMole, RAen_AU
dc.contributor.authorYu, DHen_AU
dc.contributor.authorFang, HPen_AU
dc.date.accessioned2025-01-13T02:29:01Zen_AU
dc.date.available2025-01-13T02:29:01Zen_AU
dc.date.issued2016-12-02en_AU
dc.date.statistics2024-10-30en_AU
dc.description.abstractWe experimentally observed considerable solubility of tryptophan (Trp) in a CuCl2 aqueous solution, which could reach 2-5 times the solubility of Trp in pure water. Theoretical studies show that the strong cation-π interaction between Cu2+ and the aromatic ring in Trp modifies the electronic distribution of the aromatic ring to enhance significantly the water affinity of Trp. Similar solubility enhancement has also been observed for other divalent transition-metal cations (e.g., Zn2+ and Ni2+), another aromatic amino acid (phenylalanine), and three aromatic peptides (Trp-Phe, Phe-Phe, and Trp-Ala-Phe). © 2016 American Physical Society.en_AU
dc.description.sponsorshipWe thank Yi Gao, Guanghong Wei, Jun Hu, Yusong Tu, Rongzheng Wan, and Garry Mcintyre for their constructive suggestions and helpful discussion. This work was supported by the National Natural Science Foundation of China (Grants No. 11574339, 11404361, 11290164, 11290165 and 61422509), the National Basic Research Program of China (Grant No. 2014CB339800), the Key Research Program of the Chinese Academy of Sciences (Grant No. KJZD-EW-M03), the Deepcomp7000 and ScGrid of Supercomputing Center, Computer Network Information Center of Chinese Academy of Sciences, the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase), and the Shanghai Supercomputer Center of China. We also thank the beam line 08U1A of the Shanghai Synchrotron Radiation Facilities (SSRF) for the measurements of XANES near the Cu 𝐿 edge, and the Australian Centre for Neutron Scattering, ANSTO, for access to neutron scattering facilities, and for providing technical support for the QENS measurements (P3930).en_AU
dc.format.mediumPrint-Electronicen_AU
dc.identifier.articlenumber238102en_AU
dc.identifier.citationShi, G., Dang, Y., Pan, T., Liu, X., Liu, H., Li, S., Zhang, L., Zhao, H., Li, S., Han, J., Tai, R., Zhu, Y., Li, J., Ji, Q., Mole, R. A., Yu, D., & Fang, H. (2016). Unexpectedly enhanced solubility of aromatic amino acids and peptides in an aqueous solution of divalent transition-metal cations. Physical Review Letters, 117(23), 238102. doi:10.1103/PhysRevLett.117.238102en_AU
dc.identifier.issn0031-9007en_AU
dc.identifier.issn1079-7114en_AU
dc.identifier.issue23en_AU
dc.identifier.journaltitlePhysical Review Lettersen_AU
dc.identifier.pagination238102-en_AU
dc.identifier.urihttps://doi.org/10.1103/physrevlett.117.238102en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15927en_AU
dc.identifier.volume117en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherAmerican Physical Societyen_AU
dc.subjectAmino acidsen_AU
dc.subjectSolubilityen_AU
dc.subjectAqueous solutionsen_AU
dc.subjectMetalsen_AU
dc.subjectTransition elementsen_AU
dc.subjectCationsen_AU
dc.subjectTryptophanen_AU
dc.subjectAromaticsen_AU
dc.subjectPhenylalanineen_AU
dc.subjectPeptidesen_AU
dc.titleUnexpectedly enhanced solubility of aromatic amino acids and peptides in an aqueous solution of divalent transition-metal cationsen_AU
dc.typeJournal Articleen_AU
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