Exploring the biological identity of nanoplastics

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dc.contributor.authorKihara, Sen_AU
dc.contributor.authorMata, JPen_AU
dc.contributor.authorDomigan, Len_AU
dc.contributor.authorKeoper, Ien_AU
dc.contributor.authorMcGillivray, DJen_AU
dc.date.accessioned2025-04-18T03:02:11Zen_AU
dc.date.available2025-04-18T03:02:11Zen_AU
dc.date.issued2024-07-18en_AU
dc.date.statistics2025-03-07en_AU
dc.description.abstractDespite recent attention to nanoplastics, there is still much to learn about their surface coatings that give them their “bioidentity”, which is critical to their behaviour in biological contexts. These coatings, corona, form on the particle as a complex mixtures of proteins and other surface-active chemicals – some strongly bound, and others weakly attached and exceptionally hard to study– which depend on both the particle and its environment. We show that the nature of the protein corona in simple systems depends on the surface charge and particle size of the nanoplastics, and that nanoparticles with corona can aggregate to form higher order structures, which may trigger biological stress responses. We also show that model nanoplastics strongly associate with human alveolar epithelial cells, in a manner dependent on their protein corona. However, there is much still to be learnt about the impact of complex environmental systems on these coatings, which is critical to the development of mitigation strategies for nanoplastic contamination.en_AU
dc.identifier.citationKihara, S., Mata, J., Domigan, L., Koeper, I., & McGillivray, D. (2024). Exploring the biological identity of nanoplastics. Presentation to the John White Symposium, 18th - 19th July 2024, Institut Laue Langevin, Grenoble, France. Retrieved from: https://workshops.ill.fr/event/423/contributions/1875/en_AU
dc.identifier.conferenceenddate2024-07-19en_AU
dc.identifier.conferencenameJohn White Symposium, 18th - 19th July 2024, Institut Laue Langevin,en_AU
dc.identifier.conferenceplaceGrenoble, Franceen_AU
dc.identifier.conferencestartdate2024-07-18en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16152en_AU
dc.publisherInstitut Laue Langevinen_AU
dc.relation.urihttps://workshops.ill.fr/event/423/contributions/1875/en_AU
dc.subjectMeetingsen_AU
dc.subjectPlasticsen_AU
dc.subjectSurface coatingen_AU
dc.subjectProteinsen_AU
dc.subjectParticlesen_AU
dc.subjectEnvironmenten_AU
dc.subjectContaminationen_AU
dc.titleExploring the biological identity of nanoplasticsen_AU
dc.typeConference Abstracten_AU
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