Determination of the concentration of complex boronated compounds in biological tissues by inductively coupled plasma atomic emission spectrometry
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Date
1989
Journal Title
Journal ISSN
Volume Title
Publisher
Alan R. Liss, Inc
Abstract
The application of inductively coupled plasma atomic emission spectrometry (ICP-AES) to the determination of the concentration of complex boron-containing compounds in biological tissue samples is described. Tissue digestion is achieved with perchloric acid and hydrogen peroxide in 1 hr at 75 degree C. The ICP-AES method gave a linear response for elemental boron concentration in the range 0.05 to 100 ppm and does not require the reduction of the boron to a simple species, such as boric acid. Complete recovery of boron in complex boron cluster compounds was obtained. The procedure has been applied to the determination of the boron content in compounds synthesised for neutron capture therapy and is suitable for use in biodistribution studies of such compounds, © Alan R. Liss Inc.
Description
Physical copy held by ANSTO Library at DDC: 616.99477/3
Also held as part of a journal Pigment Cell Research Vol. 2, No. 4 (1989) at the same DDC number.
Keywords
Animals, Boron, Boron compounds, Boron isotopes, Mice, Neutron capture therapy, Rats, Tissue Distribution, Medicine, Radiotherapy, Rodents, Therapy, X-ray Spectroscopy, Trace amounts, Etching, Digestion
Citation
Tamat, S. R., Moore, D. E., & Allen, B. J. (1989). Determination of the concentration of complex boronated compounds in biological tissues by inductively coupled plasma atomic emission spectrometry. Paper prsented to the 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987. In Mishima, Y. (ed.). Melanoma neutron capture therapy : proceedings of 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987, (pp. 281-285). New York : Alan R. Liss.