Does boron neutron capture therapy regress cancer?
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Date
1991-10-02
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AINSE
Abstract
In recent years a range of animal and human studies have been carried out on the uptake of boron compounds by neoplasms and their regression by Boron Neutron Capture Therapy (BNCT). Results will be presented for experiments with mice, rats rabbits, pigs, dogs and human patients from laboratories in Europe, USA, Japan and Australia.
Most of the tumour xenograft models have centred upon melanoma and glioma cancers. In addition, the majority of the biodictribution studies have involved the use of Borocaptate Sodium (BSH) and Boronophenylalanine (BPA) which have shown the most promise for BNCT. Other more recently developed compounds,which have also been trialed in rodent species, are BSSB and BOPP.
Tumour to blood boron ratios achieved after administration of BSH are in the order of 2-3. This ratio is improved to approximately 8-12 if BPA is administered. Tumour to normal tissue boron ratios for both BPA and BSH arc in the range of 3-5.
Where NCT has been employed, either thermal and epithermal neutron beams have been utilised. The therapeutic boron concentration required in the tumour is approximately 15-30 ppm. In all experiments using the thermal neutron bean, in conjunction with the boron compounds, have resulted in complete regression in approximately 60% of cases. In some models this success is as high as 80%.
This paper will review specific models, boron biodistributions attained as well as preclinical and clinical results achieved by treatment with BNCT.
Description
Physical copy held by ANSTO Library at DDC: 571.45/15
Keywords
Biological recovery, Boron compounds, Data, Experimental data, Experimental neoplasms, Melanomas, Neoplasms, Neutron capture therapy, Performance, Thermal neutrons
Citation
Mallesch, J. L., Allen, B. J., & Moore, D. E. (1991). Does boron neutron capture therapy regress cancer? Presentation to the 13th AINSE Radiation Biology Conference, 2-4 October 1991, Lucas Heights - AINSE Theatre : conference handbook (programme, abstracts and general information), (pp. 49). Lucas Heights, New South Wales : AINSE.