Small molecule interactions with lipid bilayers by neutron diffraction

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dc.contributor.authorGarvey, CJen_AU
dc.contributor.authorKent, Ben_AU
dc.contributor.authorHauß, Ten_AU
dc.contributor.authorGeorgii, Ren_AU
dc.contributor.authorDemé, Ben_AU
dc.contributor.authorCristiglio, Ven_AU
dc.contributor.authorDarwish, TAen_AU
dc.contributor.authorWu, CMen_AU
dc.contributor.authorMancera, RLen_AU
dc.contributor.authorBryant, Gen_AU
dc.date.accessioned2021-08-12T02:24:22Zen_AU
dc.date.available2021-08-12T02:24:22Zen_AU
dc.date.issued2017-07-12en_AU
dc.date.statistics2021-08-10en_AU
dc.description.abstractWhile well established for studying the internal structure of bilayers and orientation of peptides and proteins with respect to bilayers, neutron lamellar diffraction is also a powerful tool for studying the average locus of solubilisation of small molecules in stacks of lipid bilayers. The approach has provided unique insights into important issues in anhydrobiology and cryobiology, where previously only molecular dynamics simulations (MD) had been able to provide molecular scale insights. Currently we use the methodology to understand the interaction of cryo-protectants with bilayers, with the aim of providing important validation of MD parameters to further enhance the utility of the method. Here we discuss the experimental approach, both in terms of the use of contrast variation and the use of selective deuteration to simplify the extraction of scattering length density profiles within the bilayer.en_AU
dc.identifier.citationGarvey, C. J., Kent, B., Hauß, T., Georgii, R., Demé, B., Cristiglio, V., Darwish, T., Wu, C.-M., Mancera, R. L., & Bryant, G. (2017). Small molecule interactions with lipid bilayers by neutron diffraction. Paper presented at ICNS 2017 (International Conference on Neutron Scattering), Daejeon, South Korea, 9 to 13 July 2017. Retrieved from: http://www.icns2017.org/program.phpen_AU
dc.identifier.conferenceenddate13 July 2017en_AU
dc.identifier.conferencenameICNS 2017 (International Conference on Neutron Scattering)en_AU
dc.identifier.conferenceplaceDaejeon, South Koreaen_AU
dc.identifier.conferencestartdate9 July 2017en_AU
dc.identifier.urihttp://www.icns2017.org/program.phpen_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/11340en_AU
dc.language.isoenen_AU
dc.publisherInternational Conference on Neutron Scatteringen_AU
dc.subjectPeptidesen_AU
dc.subjectProteinsen_AU
dc.subjectLipidsen_AU
dc.subjectNeutron diffractionen_AU
dc.subjectCryobiologyen_AU
dc.subjectDeuterationen_AU
dc.titleSmall molecule interactions with lipid bilayers by neutron diffractionen_AU
dc.typeConference Abstracten_AU
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