Synthesis of carboranylphenylalanine for potential use in neutron capture therapy

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dc.contributor.authorPrashar, JKen_AU
dc.contributor.authorMoore, DEen_AU
dc.contributor.authorWilson, JGen_AU
dc.contributor.authorAllen, BJen_AU
dc.date.accessioned2026-01-06T05:06:27Zen_AU
dc.date.available2026-01-06T05:06:27Zen_AU
dc.date.issued1993en_AU
dc.date.statistics2025-12-16en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC. 616.9940642/3en_AU
dc.description.abstractThe successful use of p-boronophenylalanine (BPA) as the agent for the delivery of boron to melanoma for NCT is based on it being incorporated with tyrosine as a precursor for melanin synthesis. 1 Ideally for the patient undergoing NCT, the boron concentration in the tumour should reach 20 to 30 ppm, and for BPA this level can be achieved by the administration of very high doses. However, the procedure would be improved by a compound with the same affinity for the tumour but with a larger boron content. Consequently a new generation of boronated amino acids are being synthesised to take advantage of the unique bonding characteristics of boron and its ability to form cluster compounds containing up to 12 boron atoms in a compact structure. Following this approach, we have synthesised a 1,2-dicarba-closo-dodecaboranyl derivative of phenylalanine and its nido analogue. © Plenum Pressen_AU
dc.identifier.booktitleAdvances in Capture Therapy for Canceren_AU
dc.identifier.citationPrashar, J. K., Moore, D. E., Wilson. J. G., & Allen, B. J. (1993). Synthesis of carboranylphenylalanine for potential use in neutron capture therapy. Paper presented to the Fifth International Symposium on Neutron Capture Therapy for Cancer, September 14-17, Columbus, Ohio, USA. In Soloway, A. H., Barth, R. F., Carpenter, D. E. (eds) Advances in Neutron Capture Therapy, (pp. 265-268). Boston, MA : Plenum Press.en_AU
dc.identifier.conferenceenddate1992-09-17en_AU
dc.identifier.conferencenameFifth International Symposium on Neutron Capture Therapy for Canceren_AU
dc.identifier.conferenceplaceColumbus, Ohioen_AU
dc.identifier.conferencestartdate1992-09-16en_AU
dc.identifier.editorsSoloway, A. H., Barth, R. F., & Carpenter, D. E.en_AU
dc.identifier.isbn0306445670en_AU
dc.identifier.pagination265-268en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16836en_AU
dc.language.isoenen_AU
dc.publisherPlenum Pressen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectPhenylalanineen_AU
dc.subjectMelanomasen_AU
dc.subjectTumor cellsen_AU
dc.subjectAmino acidsen_AU
dc.subjectMass spectrometersen_AU
dc.subjectBoron 12en_AU
dc.titleSynthesis of carboranylphenylalanine for potential use in neutron capture therapyen_AU
dc.typeConference Paperen_AU
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