Gadolinium as an element for neutron capture therapy
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Date
1993
Journal Title
Journal ISSN
Volume Title
Publisher
Plenum Press
Abstract
Gadolinium is being studied as an alternate active element to B for Neutron Capture Therapy (NCT). The advantages of Gd-157 as compared to B-10 are that Gd-157 has a very large thermal neutron cross section (455,000 b), and Gd containing compounds that target tumors are being developed as MRI contrast agents. A disadvantage is that the products of the Gd + n reaction, gamma rays and Auger electrons, do not appear to be as well suited to NCT as the products of the B + n reaction, but these still may be effective in destroying tumors. Because of the advantages of Gd, an investigation of Gd as an element for NCT is proceeding at Brookhaven National Laboratory (BNL)1. © Plenum Press
Description
Physical copy held by ANSTO Library at DDC. 616.9940642/3
Keywords
Auger effect, DTPA, Epithermal neutrons, Gadolinium 157, Gadolinium compounds, Neutron capture therapy, Radiopharmaceuticals, Toxicity
Citation
Brugger, R. M., Liu, H. B., Laster, B. H., Gordon, C. R., Greenberg, D. D., & Warkentien, L. S. (1992). Gadolinium as an element for neutron capture therapy. Paper presented to the Fifth International Symposium on Neutron Capture Therapy for Cancer, September 13-17, Columbus, Ohio, USA. In Soloway, A. H., Barth, R. F., Carpenter, D. E. (eds) Advances in Neutron Capture Therapy, (pp. 225-229). Boston, MA : Plenum Press.