X-ray phase-contrast computed tomography for soft tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron

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dc.contributor.authorArhatari, BDen_AU
dc.contributor.authorStevenson, AWen_AU
dc.contributor.authorAbbey, Ben_AU
dc.contributor.authorNesterets, YIen_AU
dc.contributor.authorMaksimenko, Aen_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorThompson, Den_AU
dc.contributor.authorMayo, SCen_AU
dc.contributor.authorFiala, Ten_AU
dc.contributor.authorQuiney, HMen_AU
dc.contributor.authorTaba, STen_AU
dc.contributor.authorLewis, SJen_AU
dc.contributor.authorBrennan, PCen_AU
dc.contributor.authorDimmock, MRen_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorGureyev, TEen_AU
dc.date.accessioned2023-12-01T03:22:05Zen_AU
dc.date.available2023-12-01T03:22:05Zen_AU
dc.date.issued2021-04-30en_AU
dc.date.statistics2023-04-28en_AU
dc.description.abstractThe Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential for a range of biomedical X-ray applications, including radiotherapy and medical imaging experiments. One of the imaging modalities available at IMBL is propagation-based X-ray phase-contrast computed tomography (PCT). PCT produces superior results when imaging low-density materials such as soft tissue (e.g., breast mastectomies) and has the potential to be developed into a valuable medical imaging tool. We anticipate that PCT will be utilized for medical breast imaging in the near future with the advantage that it could provide better contrast than conventional X-ray absorption imaging. The unique properties of synchrotron X-ray sources such as high coherence, energy tunability, and high brightness are particularly well-suited for generating PCT data using very short exposure times on the order of less than 1 min. The coherence of synchrotron radiation allows for phase-contrast imaging with superior sensitivity to small differences in soft-tissue density. Here we also compare the results of PCT using two different detectors, as these unique source characteristics need to be complemented with a highly efficient detector. Moreover, the application of phase retrieval for PCT image reconstruction enables the use of noisier images, potentially significantly reducing the total dose received by patients during acquisition. This work is part of ongoing research into innovative tomographic methods aimed at the introduction of 3D X-ray medical imaging at the IMBL to improve the detection and diagnosis of breast cancer. Major progress in this area at the IMBL includes the characterization of a large number of mastectomy samples, both normal and cancerous, which have been scanned at clinically acceptable radiation dose levels and evaluated by expert radiologists with respect to both image quality and cancer diagnosis. © 2021 The Authors, Licensee MDPI, Basel, Switzerland. Open Access Creative Commons Attribution (CC BY).en_AU
dc.description.sponsorshipThis research was funded by NHMRC Australia, Project Grant 1138283 “Towards the clinical application of phase-contrast computed tomography in breast cancer imaging” and ANSTO project funding.en_AU
dc.identifier.articlenumber4120en_AU
dc.identifier.citationArhatari, B. D., Stevenson, A. W., Abbey, B., Nesterets, Y. I., Maksimenko, A., Hall, C. J., Thompson, D., Mayo, S. C., Fiala, T., Quiney, H. M., Taba, S. T., Lewis, S. J., Brennan, P. C., Dimmock, M., Häusermann, D., & Gureyev, T. E. (2021). X-ray phase-contrast computed tomography for soft tissue imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron. Applied Sciences, 11(9), 4120. doi:10.3390/app11094120en_AU
dc.identifier.issn2076-3417en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitleApplied Sciencesen_AU
dc.identifier.urihttps://www.mdpi.com/2076-3417/11/9/4120en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15260en_AU
dc.identifier.volume11en_AU
dc.language.isoenen_AU
dc.publisherMDPIen_AU
dc.relation.urihttps://doi.org/10.3390/app11094120en_AU
dc.subjectContrast mediaen_AU
dc.subjectMammary glandsen_AU
dc.subjectANSTOen_AU
dc.subjectTomographyen_AU
dc.subjectNeoplasmsen_AU
dc.subjectImagesen_AU
dc.titleX-ray phase-contrast computed tomography for soft tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotronen_AU
dc.typeJournal Articleen_AU
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