166dysprosium-166holmium in vivo generator

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dc.contributor.authorMirzadeh, Sen_AU
dc.contributor.authorDi Bartolo, Nen_AU
dc.contributor.authorSmith, SVen_AU
dc.contributor.authorLambrecht, RMen_AU
dc.date.accessioned2025-10-30T00:44:17Zen_AU
dc.date.available2025-10-30T00:44:17Zen_AU
dc.date.issued1983-10-10en_AU
dc.date.statistics2025-08-08en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 616.07575/115.en_AU
dc.description.abstractRecently, there has been an increasing interest in 166lHo (t1/2=26.8 n, 100% β−, Eβ av=666 Kev) for various therapeutic applications (1-2). A novel approach to deliver this isotope to tissue is via the in-vivo decay of its 81.5-h parent, 166Dy (100% β−, Eβav=l3O MeV) - an in- vivo generator system (3). lt is hoped the flexibility afforded by using this parent-daughter system may result in the reduction of radiation dose to sensitive non-target tissues which until now has limited the efficacy of the radiotherapy. In this scenario, the 166Dy-radiopharmaceutical prepared from pure 166Dy is attached to a tumour specific antibody. During the in vii/0 localisation of the radiolabelled antibody, the resultant dose to non-targeted tissues is reduced because of sub-equilibrium amounts of 166Ho. Once the l66Dy labelled radiopharmaceutical has localised in the target tissue the therapeutic dose can be generated by the decay of its 166Ho daughter. A critical question for the in vivo 166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs following the uptake of the parent at the target site. in an effort to address this question the biodistribution of 166Dg-DTPA was performed, and the bone uptake was carefully analysed for both 166Dy and 166Ho in a gamma-spectrometer employing a Ge(Li) detector. The choice of Dy-DTPA was based on a previous report (4) that the integrity of the 166Ho-DTPA complex is preserved following its formation via 166Dy-DTPA β− decay.en_AU
dc.identifier.booktitleTenth International Symposium on Radiopharmaceutical Chemistry :abstracts under the auspice of Kyoto University (October 25-28, 1983)en_AU
dc.identifier.citationMirzadeh, S., Di Bartolo, N., Smith, S, V., & Lambrecht, R. M. (1983). 166dysprosium-166holmium in vivo generator. Paper presented to the Tenth International Symposium on Radiopharmaceutical Chemistry, Kyoto University (October 25-28, 1983), (pp. 276-278). Kyoto, Japan : Kyoto University.en_AU
dc.identifier.conferenceenddate1983-10-28en_AU
dc.identifier.conferencenameTenth International Symposium on Radiopharmaceutical Chemistryen_AU
dc.identifier.conferenceplaceKyoto, Japanen_AU
dc.identifier.conferencestartdate1983-10-25en_AU
dc.identifier.editorsInternational Symposium on Radiopharmaceutical Chemistryen_AU
dc.identifier.pagination276-278en_AU
dc.identifier.placeofpublicationKyoto, Japanen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16680en_AU
dc.language.isoenen_AU
dc.publisherKyoto Universityen_AU
dc.subjectDysprosium 166en_AU
dc.subjectHolmium 166en_AU
dc.subjectIn vivoen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectTranslocationen_AU
dc.subjectUptakeen_AU
dc.subjectTherapeutic dosesen_AU
dc.subjectDataen_AU
dc.title166dysprosium-166holmium in vivo generatoren_AU
dc.typeConference Abstracten_AU
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