X-ray microbeam measurements with a high resolution scintillator fibre-optic dosimeter

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dc.contributor.authorArcher, Jen_AU
dc.contributor.authorLi, Een_AU
dc.contributor.authorPetasecca, Men_AU
dc.contributor.authorDipuglia, Aen_AU
dc.contributor.authorCameron, Men_AU
dc.contributor.authorStevenson, AWen_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.contributor.authorLerch, MLFen_AU
dc.date.accessioned2025-03-14T04:22:54Zen_AU
dc.date.available2025-03-14T04:22:54Zen_AU
dc.date.issued2017-09-29en_AU
dc.date.statistics2025-03-12en_AU
dc.description.abstractSynchrotron microbeam radiation therapy is a novel external beam therapy under investigation, that uses highly brilliant synchrotron x-rays in microbeams 50 μm width, with separation of 400 μm, as implemented here. Due to the fine spatial fractionation dosimetry of these beams is a challenging and complicated problem. In this proof-of-concept work, we present a fibre optic dosimeter that uses plastic scintillator as the radiation conversion material. We claim an ideal one-dimensional resolution of 50 μm. Using plastic scintillator and fibre optic makes this dosimeter water-equivalent, a very desirable dosimetric property. The dosimeter was tested at the Australian Synchrotron, on the Imaging and Medical Beam-Line. The individual microbeams were able to be resolved and the peak-to-valley dose ratio and the full width at half maximum of the microbeams was measured. These results are compared to a semiconductor strip detector of the same spatial resolution. A percent depth dose was measured and compared to data acquired by an ionisation chamber. The results presented demonstrate significant steps towards the development of an optical dosimeter with the potential to be applied in quality assurance of microbeam radiation therapy, which is vital if clinical trials are to be performed on human patients. © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_AU
dc.description.sponsorshipThis project was supported by UOW’s Global Challenges Program. This research was undertaken on the Imaging and Medical beamline at the Australian Synchrotron, Victoria, Australia (AS162/IMBL/10829). Authors JA, EL, AD, MC and ML acknowledge the support of the Australian NH&MRC (APP1093256). This research has been conducted with the support of the Australian Government Research Training Program Scholarship.en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber12450en_AU
dc.identifier.citationArcher, J., Li, E., Petasecca, M., Dipuglia, A., Cameron, M., Stevenson, A., Hall, C., Hausermann, D., Rosenfeld, A., & Lerch, M. (2017). X-ray microbeam measurements with a high resolution scintillator fibre-optic dosimeter. Scientific Reports, 7(1), 12450. doi:10.1038/s41598-017-12697-6en_AU
dc.identifier.issn2045-2322en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleScientific Reportsen_AU
dc.identifier.urihttps://doi.org/10.1038/s41598-017-12697-6en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16063en_AU
dc.identifier.volume7en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherSpringer Natureen_AU
dc.subjectResolutionen_AU
dc.subjectSynchrotronsen_AU
dc.subjectRadiotherapyen_AU
dc.subjectClinical trialsen_AU
dc.subjectSemiconductor detectorsen_AU
dc.subjectScintillationsen_AU
dc.subjectFiber Opticsen_AU
dc.subjectDosimetryen_AU
dc.subjectMeasuring instrumentsen_AU
dc.subjectANSTOen_AU
dc.subjectAustralian organizationsen_AU
dc.titleX-ray microbeam measurements with a high resolution scintillator fibre-optic dosimeteren_AU
dc.typeJournal Articleen_AU
dcterms.dateAccepted2017-09-18en_AU
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