Drug-induced morphology transition of self-assembled glycopolymers: insight into the drug-polymer interaction

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dc.contributor.authorCao, Cen_AU
dc.contributor.authorZhao, JCen_AU
dc.contributor.authorChen, Fen_AU
dc.contributor.authorLu, MGen_AU
dc.contributor.authorKhine, YYen_AU
dc.contributor.authorMacmillanc, Aen_AU
dc.contributor.authorGarvey, CJen_AU
dc.contributor.authorStenzel. Men_AU
dc.date.accessioned2023-11-22T22:09:21Zen_AU
dc.date.available2023-11-22T22:09:21Zen_AU
dc.date.issued2018-11-18en_AU
dc.date.statistics2023-05-24en_AU
dc.description.abstractIt is often assumed that a hydrophobic drug will be entrapped in the hydrophobic environment of a micelle. Little attention is usually drawn to the actual location of the drug and the effect of the drug on properties. In this publication, we show how the chosen drug curcumin is not only unexpectedly located in the shell of the micelle, but that the accumulation in the hydrophilic block can lead to changes in morphology during self-assembly. A block copolymer poly(1-O-methacryloyl -β-D-fructopyranose)-b-poly(methyl methacrylate), Poly(1-O-MAFru)36-b-PMMA192, was loaded with different amounts of curcumin. The resulting self-assembled nanoparticles were analyzed using TEM, SAXS, and SANS. Initial microscopy evidence revealed that the presence of the drug induces morphology changes from cylindrical micelles (no drug) to polymersomes, which decreased in size with increasing amount of drug (Figure 1). SAXS and SANS analysis, supported by fluorescence studies, revealed that the drug is interacting with the glycopolymer block. The drug did not only influence the shape of the drug carrier, but also the level of cof the shell. Increasing the amount of drug dehydrated the nanoparticle shell, which coincided with a lower nanoparticle uptake by MCF-7 breast cancer cells and non-cancerous Raw-264.7 cells. As a result, we showed that the drug can influence the behaviour of the fluorescence in terms of shape and shell hydration, which could influence the performance in a biological setting (Figure 1). Although the depicted scenario may not apply to every drug carrier, it is worth evaluation if the drug will interfere in unexpected ways, for example, when the drug locates on the surface and affects the internal structure of the nanocarrier. © The Authors.en_AU
dc.identifier.citationCao, C., Zhao, J., Chen, F., Lu, M., Khine, Y. Y., Macmillane, A., Garvey, C., & Stenzel. M. (2018). Drug-induced morphology transition of self-assembled glycopolymers: insight into the drug-polymer interaction. Presentation to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018, AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234, Australia, Monday 19 November 2018 - Wednesday 21 November 2018, (pp. 6). Retrieved from https://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.identifier.conferenceenddate2018-11-21en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2018en_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate2018-11-19en_AU
dc.identifier.pagination6en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15237en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.subjectDrugsen_AU
dc.subjectHydrationen_AU
dc.subjectNanoparticlesen_AU
dc.subjectDehydrationsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectMammary glandsen_AU
dc.titleDrug-induced morphology transition of self-assembled glycopolymers: insight into the drug-polymer interactionen_AU
dc.typeConference Abstracten_AU
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