New contrast options - diversity and specifity of deuteration

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dc.contributor.authorHolden, PJen_AU
dc.contributor.authorCagnes, MPen_AU
dc.contributor.authorDavydova, Nen_AU
dc.contributor.authorDuff, APen_AU
dc.contributor.authorHoward, JKen_AU
dc.contributor.authorKrause-Heuer, AMen_AU
dc.contributor.authorYepuri, NRen_AU
dc.contributor.authorDarwish, TAen_AU
dc.date.accessioned2024-01-10T22:53:03Zen_AU
dc.date.available2024-01-10T22:53:03Zen_AU
dc.date.issued2018-11-19en_AU
dc.date.statistics2023-07-06en_AU
dc.description.abstractThe Australian National Deuteration Facility (NDF) continues to develop new capabilities in molecular deuteration. The tailoring of deuteration approach to solve specific contrast problems has greatly increased the range of systems that can be investigated and recent capability development and new applications will be described. The common problem of how to obtain good contrast during SANS of membrane proteins solubilised in detergent micelles has been solved by specific deuteration of detergent head groups and hydrophobic tails to different levels to contrast match at 100% D20 buffer. Likewise, in investigating the lo cation of a purely hydrophobic transmembrane peptide in bicontinuous cubic phase liquid crystals Page 25 ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018 / Book of Abstracts suitable for drug delivery, a mixture of deuterated and hydrogenated phytanoyl monoethanolamide was used to perfectly contrast match out either gyroid or diamond phase lipids to pinpoint the peptides location. In Soft Matter, investigation of structure of the ligands in the shell layer of self-assembled monolayerprotected nanoparticles has been made possible by use of various combinations of immiscible deuterated or hydrogenated Phenylethanethiol (PET) and Dodecanethiol (DDT) and MONSA modelling of SANS data showed the janus and belt like distribution of the ligands on the surface and the effects of nanoparticle core size and ligand ratio on the patterning. Other case studies will include use of deuterated ionic liquids and new previously unavailable deuterated molecules will be highlighted. This work was supported by the National Collaborative Research Infrastructure Strategy © The Authors.en_AU
dc.identifier.citationHolden, P., Cagnes, M., Davydova, N., Duff, A., Howard, J., Krause-Heuer, A., Yepuri, R., & Darwish, T. (2018). New contrast options - diversity and specifity of deuteration. Presentation to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018, AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234, Australia, Monday 19 November 2018 - Wednesday 21 November 2018, (pp. 25-26). Retrieved from https://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.identifier.conferenceenddate2021-11-21en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2018en_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate2021-11-19en_AU
dc.identifier.pagination25-26en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15303en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.subjectAustralian organizationsen_AU
dc.subjectDeuterationen_AU
dc.subjectMembrane proteinsen_AU
dc.subjectDetergentsen_AU
dc.subjectBuffersen_AU
dc.subjectNanoparticlesen_AU
dc.subjectPeptidesen_AU
dc.subjectLiquid crystalsen_AU
dc.titleNew contrast options - diversity and specifity of deuterationen_AU
dc.typeConference Abstracten_AU
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