Dietary uptake and depuration kinetics of perfluorooctane sulfonate, perfluorooctanoic acid, and hexafluoropropylene oxide dimer acid (GenX) in a benthic fish

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dc.contributor.authorHassell, KLen_AU
dc.contributor.authorCoggan, TLen_AU
dc.contributor.authorCresswell, Ten_AU
dc.contributor.authorKolobaric, Aen_AU
dc.contributor.authorBerry, Ken_AU
dc.contributor.authorCrosbie, NDen_AU
dc.contributor.authorBlackbeard, Jen_AU
dc.contributor.authorPettigrove, VJen_AU
dc.contributor.authorClarke, BOen_AU
dc.date.accessioned2021-12-09T22:07:11Zen_AU
dc.date.available2021-12-09T22:07:11Zen_AU
dc.date.issued2019-11-21en_AU
dc.date.statistics2021-11-19en_AU
dc.description.abstractPer- and poly-fluoroalkyl substances (PFAS) are ubiquitously distributed throughout aquatic environments and can bioaccumulate in organisms. We examined dietary uptake and depuration of a mixture of 3 PFAS: perfluorooctanoic acid (PFOA; C8HF15O2), perfluorooctane sulfonate (PFOS; C8HF17SO3), and hexafluoropropylene oxide dimer acid (HPFO-DA; C6HF11O3; trade name GenX). Benthic fish (blue spot gobies, Pseudogobius sp.) were fed contaminated food (nominal dose 500 ng g–1) daily for a 21-d uptake period, followed by a 42-d depuration period. The compounds PFOA, linear-PFOS (linear PFOS), and total PFOS (sum of linear and branched PFOS) were detected in freeze-dried fish, whereas GenX was not, indicating either a lack of uptake or rapid elimination (<24 h). Depuration rates (d–1) were 0.150 (PFOA), 0.045 (linear-PFOS), and 0.042 (linear+branched-PFOS) with corresponding biological half-lives of 5.9, 15, and 16 d, respectively. The PFOS isomers were eliminated differently, resulting in enrichment of linear-PFOS (70–90%) throughout the depuration period. The present study is the first reported study of GenX dietary bioaccumulation potential in fish, and the first dietary study to investigate uptake and depuration of multiple PFASs simultaneously, allowing us to determine that whereas PFOA and PFOS accumulated as expected, GenX, administered in the same way, did not appear to bioaccumulate. © 2019 SETACen_AU
dc.description.sponsorshipThe present study was funded by the Melbourne Water Corporation with additional resources provided by the Centre for Aquatic Pollution Identification and Management, the University of Melbourne, the Royal Melbourne Institute of Technology University, and the Victorian Marine Sciences Consortiumen_AU
dc.identifier.citationHassell, K. L., Coggan, T. L., Cresswell, T., Kolobaric, A., Berry, K., Crosbie, N. D., Blackbeard, J., Pettigrove, V. J. & Clarke, B. O. (2020). Dietary uptake and depuration kinetics of perfluorooctane sulfonate, perfluorooctanoic acid, and hexafluoropropylene oxide dimer acid (GenX) in a benthic fish. Environmental Toxicology and Chemistry, 39(3), 595-603. doi:10.1002/etc.4640en_AU
dc.identifier.issn1552-8618en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleEnvironmental Toxicology and Chemistryen_AU
dc.identifier.pagination595-603en_AU
dc.identifier.urihttps://doi.org/10.1002/etc.4640en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12406en_AU
dc.identifier.volume39en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley & Sons, Incen_AU
dc.subjectBiological accumulationen_AU
dc.subjectFishesen_AU
dc.subjectDieten_AU
dc.subjectFooden_AU
dc.subjectAquatic ecosystemsen_AU
dc.subjectAquatic organismsen_AU
dc.titleDietary uptake and depuration kinetics of perfluorooctane sulfonate, perfluorooctanoic acid, and hexafluoropropylene oxide dimer acid (GenX) in a benthic fishen_AU
dc.typeJournal Articleen_AU
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