Structures of biliary micelles during solubilisation of lipids mimicking the digestion products of human and bovine milk

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dc.contributor.authorClulow, AJen_AU
dc.date.accessioned2023-08-04T03:49:47Zen_AU
dc.date.available2023-08-04T03:49:47Zen_AU
dc.date.issued2021-11-24en_AU
dc.date.statistics2023-04-21en_AU
dc.descriptionThis was an oral presentation only.en_AU
dc.description.abstractMilk is our sole source of nutrition for the first six months of life and milk lipids carry fat-soluble nutrients through the gut as well as providing most of the energy we consume with milk. The digestion and absorption of lipids, predominantly triglycerides, and entrained nutrients is therefore important for survival and growth. Milk triglycerides are regarded amongst the most chemically complex mixtures, their composition is species-dependent and determines the mixture of fatty acids and monoglycerides that form during their digestion. Most lipid digestion takes place in the small intestines where bile salts mixed with phospholipids in the intestinal fluids form a colloidal sink into which the poorly-soluble digestion products can partition and be absorbed at the intestinal walls. This work describes attempts to simulate how the structures of biliary micelles change when they absorb milk digestion products under intestinal conditions. Mixtures of fatty acids and monoglycerides were prepared to mimic the digestion products of human and bovine milk. The chemical complexity of the mixtures was varied by including between four and eight different lipid chain types in the digestion product mixtures. The effect of pH on micelle structure was also studied within the range of pH 6.4-7.7, consistent with the increase in pH along the intestinal tract. The structural differences when these complex lipid mixtures were solubilised by bile salt/phospholipid micelles were identified using the SAXS/WAXS beamline at the ANSTO Australian Synchrotron. The lipid composition was found to be a primary driver of micelle shape and size, with pH having a secondary affect in reducing aggregate formation at higher pH. © 2021 The Authorsen_AU
dc.identifier.citationClulow, A. (2021). Structures of biliary micelles during solubilisation of lipids mimicking the digestion products of human and bovine milk. Presentation to the ANSTO User Meeting, Online, 24-26 November 2021. Retrieved from: https://events01.synchrotron.org.au/event/146/contributions/4258/en_AU
dc.identifier.conferenceenddate2021-11-26en_AU
dc.identifier.conferencenameANSTO User Meeting 2021en_AU
dc.identifier.conferenceplaceOnlineen_AU
dc.identifier.conferencestartdate2021-11-24en_AU
dc.identifier.urihttps://events01.synchrotron.org.au/event/146/contributions/4258/en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15086en_AU
dc.language.isoenen_AU
dc.publisherAustralian Nuclear Science and Technology Organisationen_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/146/contributions/4258/en_AU
dc.subjectMilken_AU
dc.subjectMammary glandsen_AU
dc.subjectLactationen_AU
dc.subjectLipidsen_AU
dc.subjectNutrientsen_AU
dc.subjectTriglyceridesen_AU
dc.subjectFatty acidsen_AU
dc.subjectBeamlinesen_AU
dc.subjectANSTOen_AU
dc.titleStructures of biliary micelles during solubilisation of lipids mimicking the digestion products of human and bovine milken_AU
dc.typeConference Presentationen_AU
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