Microgravity × radiation: a space mechanobiology approach toward cardiovascular function and disease

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dc.contributor.authorBasirun, Cen_AU
dc.contributor.authorFerlazzo, MLen_AU
dc.contributor.authorHowell, NRen_AU
dc.contributor.authorLiu, GJen_AU
dc.contributor.authorMiddleton, RJen_AU
dc.contributor.authorMartinac, Ben_AU
dc.contributor.authorNarayanan, SAen_AU
dc.contributor.authorPoole, Ken_AU
dc.contributor.authorGentile, Cen_AU
dc.contributor.authorChou, Jen_AU
dc.date.accessioned2022-08-29T00:58:46Zen_AU
dc.date.available2022-08-29T00:58:46Zen_AU
dc.date.issued2021-10-29en_AU
dc.date.statistics2022-08-01en_AU
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en_AU
dc.description.abstractIn recent years, there has been an increasing interest in space exploration, supported by the accelerated technological advancements in the field. This has led to a new potential environment that humans could be exposed to in the very near future, and therefore an increasing request to evaluate the impact this may have on our body, including health risks associated with this endeavor. A critical component in regulating the human pathophysiology is represented by the cardiovascular system, which may be heavily affected in these extreme environments of microgravity and radiation. This mini review aims to identify the impact of microgravity and radiation on the cardiovascular system. Being able to understand the effect that comes with deep space explorations, including that of microgravity and space radiation, may also allow us to get a deeper understanding of the heart and ultimately our own basic physiological processes. This information may unlock new factors to consider with space exploration whilst simultaneously increasing our knowledge of the cardiovascular system and potentially associated diseases. © 2021 Basirun, Ferlazzo, Howell, Liu, Middleton, Martinac, Narayanan, Poole, Gentile and Chou.en_AU
dc.description.sponsorshipThe author acknowledges the support of the Australian Research Council Discovery Project (ARC DP) [DP190101973 to JC, the support of The University of Sydney (Cardiothoracic Surgery Research Grant)], UTS (Seed Funding), and Catholic Archdiocese of Sydney (Grant for Adult Stem Cell Research), Ian Potter Foundation Grant to CG.en_AU
dc.identifier.articlenumber750775en_AU
dc.identifier.citationBasirun, C., Ferlazzo, M. L., Howell, N. R., Liu, G.-J., Middleton, R. J., Martinac, B., Narayanan, S. A., Poole, K., Gentile, C. & Chou, J. (2021). Microgravity x radiation: a space mechanobiology approach toward cardiovascular function and disease. Frontiers in Cell and Developmental Biology, 9, 750775. doi:10.3389/fcell.2021.750775en_AU
dc.identifier.issn2296-634Xen_AU
dc.identifier.journaltitleFrontiers in Cell and Developmental Biologyen_AU
dc.identifier.urihttps://doi.org/10.3389/fcell.2021.750775en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/13635en_AU
dc.identifier.volume9en_AU
dc.language.isoenen_AU
dc.publisherFrontiers Media S.A.en_AU
dc.subjectCosmic radiationen_AU
dc.subjectCardiovascular systemen_AU
dc.subjectCardiovascular diseasesen_AU
dc.subjectSpace flighten_AU
dc.subjectGravitationen_AU
dc.subjectWeightlessnessen_AU
dc.titleMicrogravity × radiation: a space mechanobiology approach toward cardiovascular function and diseaseen_AU
dc.typeJournal Articleen_AU
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