Peformance evaluation of preclinical PET scanners with the NEMA NU-4 image quality phantom using a collection of radioisotopes

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dc.contributor.authorNezich, Ren_AU
dc.contributor.authorReilhac, Aen_AU
dc.contributor.authorZahra, Den_AU
dc.contributor.authorPrice, Ren_AU
dc.date.accessioned2021-08-11T04:38:56Zen_AU
dc.date.available2021-08-11T04:38:56Zen_AU
dc.date.issued2013-04-13en_AU
dc.date.statistics2021-08-10en_AU
dc.descriptionOpen Accessen_AU
dc.description.abstractBackground: The radioisotopes 18F, 11C, 124I, 68Ga, 89Zr and 64Cu have found numerous applications in small animal PET imaging, and this entire subset of isotopes will soon be available to Australian preclinical researchers. The suitability of an isotope for a given imaging application is determined largely by its radioactive half-life. However, other characteristic physical properties of the isotope such as the branching fraction and positron energy can severely impact image quality and the ability to accurately quantify uptake of the radio-labelled molecule. Furthermore, the specific acquisition parameters and reconstruction algorithms employed to generate the image can significantly affect the image quality and quantification accuracy. The NEMA NU-4 2008 standards describe a method to evaluate the performance of small animal PET scanners. The information gathered through the NEMA Image Quality phantom scanning experiment is valuable for optimising the scanner usage, because it allows for the best selection of acquisition/reconstruction protocols and provides knowledge of the resolution limits of the system. Method: NEMA NU-4 image quality phantom performance testing was performed on the Siemens Inveon with 18F, 124I and 64Cu, using default acquisition parameters and each of the available reconstruction algorithms. Further testing will be performed using 11C, 68Ga and 89Zr. The Bioscan NanoPET scanner will be tested with all of the mentioned isotopes. Results: The figure shows NU-4 phantom images obtained for 18F, 64Cu and 124I; using the Inveon preclinical scanner and FBP2D reconstruction. The relatively poor image quality obtained with 124I is mainly caused by single gamma-photon contamination. Due to a higher positron range, recovery coefficients obtained with 124I are well below the values measured with 18F. Conclusion: NEMA NU-4 performance testing provides valuable information about the image quality achievable for a given PET scanner and radioisotope. © 2003 John Wiley & Sons, Inc.en_AU
dc.identifier.citationNezich, R., Reilhac, A., Zahra, D., & Price, R. (2013). Peformance evaluation of preclinical PET scanners with the NEMA NU-4 image quality phantom using a collection of radioisotopes. Poster presented at the 43rd Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine (ANZSNM), 11-15 April, 2013, Perth Convention and Exhibition Centre, Perth Australia. In Internal Medicine Journal, 43 (S1), 23. doi:10.1111/imj.12133en_AU
dc.identifier.conferenceenddate15 September 2013en_AU
dc.identifier.conferencename43rd Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine (ANZSNM)en_AU
dc.identifier.conferenceplacePerth, Australiaen_AU
dc.identifier.conferencestartdate11 September 2013en_AU
dc.identifier.issn1445-5994en_AU
dc.identifier.issueS1en_AU
dc.identifier.journaltitleInternal Medicine Journalen_AU
dc.identifier.pagination23en_AU
dc.identifier.urihttps://doi.org/10.1111/imj.12133en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/11318en_AU
dc.identifier.volume43en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley & Sons, Inc.en_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRadioisotope scanningen_AU
dc.subjectAnimalsen_AU
dc.subjectBiological half-lifeen_AU
dc.subjectIsotopesen_AU
dc.subjectFluorine 18en_AU
dc.subjectImagesen_AU
dc.titlePeformance evaluation of preclinical PET scanners with the NEMA NU-4 image quality phantom using a collection of radioisotopesen_AU
dc.typeConference Posteren_AU
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