Chemical deuteration and neutrons for structure function applications

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dc.contributor.authorDarwish, TAen_AU
dc.contributor.authorYepuri, NRen_AU
dc.contributor.authorHeuer, AKen_AU
dc.contributor.authorCagnes, MPen_AU
dc.contributor.authorHolden, PJen_AU
dc.date.accessioned2021-10-26T21:35:15Zen_AU
dc.date.available2021-10-26T21:35:15Zen_AU
dc.date.issued2016-11-29en_AU
dc.date.statistics2021-10-11en_AU
dc.description.abstractIn small angle neutron scattering and neutron reflectometry studies, the use of mixtures of deuterated and hydrogenated solvents to manipulate scattering length density and achieve contrast variation is widespread. This approach, while useful is less effective for multicomponent organic systems containing molecules of similar scattering length densities. In such systems molecular deuteration is necessary to achieve contrast between the different components and it significantly increases the options in structure function investigations. There have been limited global initiatives in the field of molecular deuteration where the majority of these programs focus on biological deuteration of proteins and lipids, while more complex deuterated small molecules haven’t been widely available to the neutron community. This has limited the experiments that can be performed, and formed a bottle neck for advancing the applications of neutron scattering. In this paper we will discuss the recent advancements and the impact of deuteration on the research outcomes achieved by using deuterated molecules produced by the chemical deuteration laboratories at ANSTO’s National Deuteration Facility. Recent high-impact case studies will be presented which reveal the exciting and diverse characterisation studies which are now available for the neutron community. The chemical deuteration of surfactants, sugars, heterocyclic and aromatic compounds has made possible a wide range of investigations systems in the fields of molecular electronics, structural biology, and biotechnology.en_AU
dc.identifier.citationDarwish, T. A., Yepuri, N. R., Heuer, A. K., Cagnes, M., & Holden, P. (2016). Chemical deuteration and neutrons for structure function applications. Paper presented at 13th AINSE-ANBUG Neutron Scattering Symposium, Sydney, NSW, Australia, 29-30 November 2016.en_AU
dc.identifier.conferenceenddate30 November 2016en_AU
dc.identifier.conferencename13th AINSE-ANBUG Neutron Scattering Symposiumen_AU
dc.identifier.conferenceplaceSydney, NSW, Australiaen_AU
dc.identifier.conferencestartdate29 November 2016en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12097en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineeringen_AU
dc.subjectNeutron diffractionen_AU
dc.subjectNeutron reflectorsen_AU
dc.subjectDeuterationen_AU
dc.subjectHydrogenationen_AU
dc.subjectSolventsen_AU
dc.subjectProteinsen_AU
dc.subjectLipidsen_AU
dc.subjectANSTOen_AU
dc.titleChemical deuteration and neutrons for structure function applicationsen_AU
dc.typeConference Abstracten_AU
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