157Gd-neutron capture: potential of 157Gd-labelled DNA ligands for neutron capture therapy
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Date
1992
Journal Title
Journal ISSN
Volume Title
Publisher
Plenum Press
Abstract
The classical feature of BNCT is the limited range of the fission products of the 10B-NC reaction. Although there are other nuclides with higher thermal neutron capture cross sections than that of 10B, these have been considered of limited value for NCT because they are all n, gamma reactions. However, 157Gd, which has the highest thermal neutron capture cross section (250,000 barns) has been reevaluated in recent years 1,2. We have been particularly interested in the possibility of exploiting the internal conversion and consequent Auger electron emission associated with the n-gamma reaction. Experiments with 157Gd3+ and plasmid DNA demonstrated that DNA-associated 157Gd-NC induces DNA double-strand breaks1. DNA-breakage was reduced by sequestering the Gd3+ from DNA by addition of EDTA, reflecting the limited range of Auger electrons, which is well-established3 from experiments with Auger-emitting isotopes such as 125I. These results demonstrate the potential of 157Gd-DNA ligands for NCT, by analogy with the radiobiological effectiveness of 125I decay in DNA3. © Plenum Press
Description
Physical copy held by ANSTO Library at DDC: 616.994/17
Keywords
Gadolinium 157, Neutron capture therapy, DNA, Labelling, Ligands, Boron 10, Radiobiology, Genome mutations, Gamma radiation, Fluorescence spectroscopy, Chromosomes
Citation
Martin, R. F., Haigh, A., Monger, C., Pardee, M., Whittaker, A. D., Kelly, D. P., & Allen, B. J. (1992). 157Gd-neutron capture: potential of 157Gd-labelled DNA ligands for neutron capture therapy. Paper presented to the Fourth International Symposium on Neutron Capture Therapy for Cancer, December 4-7, 1990, Sydney, Australia. In B. J. Allen, D. E. Moore, & B. V. Harrington (Eds.), Progress in Neutron Capture Therapy for Cancer (pp. 357-360). New York, USA: Plenum Press.