The spinal cord as organ of risk: assessment for acute and subacute neurological adverse effects after microbeam radiotherapy in a rodent model

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dc.contributor.authorJaekel, Fen_AU
dc.contributor.authorPaino, JRen_AU
dc.contributor.authorEngels, Een_AU
dc.contributor.authorKlein, Men_AU
dc.contributor.authorBarnes, Men_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorZheng, Gen_AU
dc.contributor.authorWang, HXen_AU
dc.contributor.authorHildebrandt, Gen_AU
dc.contributor.authorLerch, MLFen_AU
dc.contributor.authorSchültke, Een_AU
dc.date.accessioned2025-02-28T00:40:50Zen_AU
dc.date.available2025-02-28T00:40:50Zen_AU
dc.date.issued2023-04-26en_AU
dc.date.statistics2025-02-19en_AU
dc.description.abstractMicrobeam radiotherapy (MRT), a high dose rate radiotherapy technique using spatial dose fractionation at the micrometre range, has shown a high therapeutic efficacy in vivo in different tumour entities, including lung cancer. We have conducted a toxicity study for the spinal cord as organ of risk during irradiation of a target in the thoracic cavity. In young adult rats, the lower thoracic spinal cord was irradiated over a length of 2 cm with an array of quasi-parallel microbeams of 50 µm width, spaced at a centre-to-centre distance of 400 µm, with MRT peak doses up to 800 Gy. No acute or subacute adverse effects were observed within the first week after irradiation up to MRT peak doses of 400 Gy. No significant differences were seen between irradiated animals and non-irradiated controls in motor function and sensitivity, open field test and somatosensory evoked potentials (SSEP). After irradiation with MRT peak doses of 450–800 Gy, dose-dependent neurologic signs occurred. Provided that long-term studies do not reveal significant morbidity due to late toxicity, an MRT dose of 400 Gy can be considered safe for the spinal cord in the tested beam geometry and field size. © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber2470en_AU
dc.identifier.citationJaekel, F., Paino, J., Engels, E., Klein, M., Barnes, M., Häusermann, D., Hall, C., Zheng, G., Wang, H., Hildebrandt, G., Lerch, M., & Schültke, E. (2023). The spinal cord as organ of risk: assessment for acute and subacute neurological adverse effects after microbeam radiotherapy in a rodent model. Cancers, 15(9), 2470. doi:2072-6694/15/9/2470en_AU
dc.identifier.issn2072-6694en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitleCancersen_AU
dc.identifier.urihttps://doi.org/10.3390/cancers15092470en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16002en_AU
dc.identifier.volume15en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherMDPIen_AU
dc.subjectSpinal Corden_AU
dc.subjectOrgansen_AU
dc.subjectRadiotherapyen_AU
dc.subjectRodentsen_AU
dc.subjectToxicityen_AU
dc.subjectIrradiationen_AU
dc.subjectDose limitsen_AU
dc.subjectClinical trialsen_AU
dc.subjectDosimetryen_AU
dc.subjectNMR imagingen_AU
dc.titleThe spinal cord as organ of risk: assessment for acute and subacute neurological adverse effects after microbeam radiotherapy in a rodent modelen_AU
dc.typeJournal Articleen_AU
dcterms.dateAccepted2023-04-24en_AU
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