Tuning hydrogels through metal-based gelation triggers

Simple item page
dc.contributor.authorMcEwen, Hen_AU
dc.contributor.authorDu, EYen_AU
dc.contributor.authorMata, JPen_AU
dc.contributor.authorThordarson, Pen_AU
dc.contributor.authorMartin, ADen_AU
dc.date.accessioned2024-01-12T04:53:50Zen_AU
dc.date.available2024-01-12T04:53:50Zen_AU
dc.date.issued2017-11-18en_AU
dc.date.statistics2023-11-20en_AU
dc.description.abstractTwo N-terminal capped tripeptides have been synthesised and display remarkable versatility in their gelation behaviour. Here, gelation can be triggered through the addition of an acid, biologically relevant metal salts or cell culture media. The structural and mechanical properties of the resultant hydrogels are tuneable, with gelation triggered through sodium cations amplifying secondary structure organisation yet decreasing gel stiffness. The effect of gelation trigger on cell viability is evaluated, with substantial improvement in cell survival observed when gelation is triggered using metal salts or cell culture media. © 2017 The Royal Society of Chemistryen_AU
dc.description.sponsorshipWe would like to thank the Mark Wainwright Analytical Centre (UNSW) for access to instruments. We acknowledge the Australian Research Council for a Discovery Project grant (DP130101512), an ARC Centre of Excellence grant (CE140100036) and a Future Fellowship (FT120100101) to PT and the National Health and Medical Research Council for a Dementia Research Fellowship (APP1106751) to ADM. We would also like to thank the Australian Government for award of a PhD scholarship to ED. We would also like to thank the Australian Nuclear Science and Technology Organisation (ANSTO) for access to the QUOKKA SANS beamline.en_AU
dc.identifier.citationMcEwen, H., Du, E. Y., Mata, J. P., Thordarson, P., & Martin, A. D. (2017). Tuning hydrogels through metal-based gelation triggers. Journal of Materials Chemistry B, 5(47), 9412-9417. doi:10.1039/C7TB02140Ben_AU
dc.identifier.issn2050-7518en_AU
dc.identifier.issue47en_AU
dc.identifier.journaltitleJournal of Materials Chemistry Ben_AU
dc.identifier.pagination9412-9417en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15350en_AU
dc.identifier.volume5en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chemistryen_AU
dc.relation.urihttps://doi.org/10.1039/C7TB02140Ben_AU
dc.subjectHydrogelsen_AU
dc.subjectMetalsen_AU
dc.subjectGelationen_AU
dc.subjectPeptidesen_AU
dc.subjectCationsen_AU
dc.subjectCell culturesen_AU
dc.titleTuning hydrogels through metal-based gelation triggersen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles