Monte Carlo calculation of microbeam radiation in a tissue/lung/tissue phantom

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dc.contributor.authorCompany, FZen_AU
dc.contributor.authorAllen, BJen_AU
dc.contributor.authorMiskelly, Pen_AU
dc.date.accessioned2022-08-09T06:37:23Zen_AU
dc.date.available2022-08-09T06:37:23Zen_AU
dc.date.issued1994-11-16en_AU
dc.date.statistics2022-04-07en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC 541.382/16.en_AU
dc.description.abstractRecent advances in synchrotron generated X-ray beams with high fluence rate, small divergence and sharply defined microbeam margins permit investigation of the application of an array of closely spaced, parallel or converging microbeams in radiotherapy. The proposed technique takes advantage of the hypothesis repair mechanism of capillary cells between alternate microbeam zones, which regenerates the lethally irradiated capillaries. Unlike a pencil beam, more accurate dose calculation, beam width and spacing are essential to minimise radiation damage to normal tissue cells outside the target. The absorbed dose between microbeam zones should be kept below the threshold for radiation damage. Thus the peak-to-valley ratio for the dose distribution should be optimized. The absorbed dose profile depends on the energy of the incident beam and the composition and density of the medium. In this study, using Monte Carlo computations, the radial absorbed dose of single 24 x 24 μm2 cross-section X-ray beams of 100 and 300 keV in a tissue/lung/tissue phantom are investigated. Two parallel, 100 keV, 24 x 24 μm2 cross-section beams, using 200 μm center-to-center spacing, give similar peak-to-valley ratio in both media at the same depth. These results indicate that at 100 KeV, closely spaced microbeam therapy can be applied to the lung as well as the tissue. It is found that in the 300 keV region the peak-to-valley ratio decreases 200 times compared with 100 KeV. At the center of a bundle of a 1 x 1 cm2 cross-section, 200 μm center-to-center microbeams, the ratio approaches unity, indicating the unsuitability of this energy region when using closely spaced microbeam therapy. In the 33 KeV region the peak-to-valley ratio is similar to the 100 KeV. The relatively high surface absorbed dose of 33 KeV microbeam rules out its possible application in the deep microbeam therapy.en_AU
dc.identifier.citationCompany, F. Z., Allen, B. J., & Miskelly, P. (1994), Monte Carlo calculation of microbeam radiation in a tissue/lung/tissue phantom. Paper presented to the AINSE Conference on Radiation Biology and Chemistry, Cuming Theatre, Chemistry Department, The University of Melbourne, Melbourne, Victoria, 16-18 November 1994, (pp. 16).en_AU
dc.identifier.conferenceenddate18 November 1994en_AU
dc.identifier.conferencenameAINSE Conference on Radiation Biology and Chemistryen_AU
dc.identifier.conferenceplaceMelbourne, Victoriaen_AU
dc.identifier.conferencestartdate16 November 1994en_AU
dc.identifier.isbn9780959847260en_AU
dc.identifier.otherPoster no. 5en_AU
dc.identifier.pagination16en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/13496en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineeringen_AU
dc.subjectLungsen_AU
dc.subjectMonte Carlo Methoden_AU
dc.subjectPhantomsen_AU
dc.subjectRadiation dosesen_AU
dc.subjectRadiotherapyen_AU
dc.subjectSynchrotron radiationen_AU
dc.subjectX-ray sourcesen_AU
dc.subjectAnimal tissuesen_AU
dc.titleMonte Carlo calculation of microbeam radiation in a tissue/lung/tissue phantomen_AU
dc.typeConference Posteren_AU
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