Influence of momentum acceptance on range monitoring of 11C and 15O ion beams using in-beam PET

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dc.contributor.authorMohammadi, Aen_AU
dc.contributor.authorTashima, Hen_AU
dc.contributor.authorIwao, Yen_AU
dc.contributor.authorTakyu, Sen_AU
dc.contributor.authorAkamatsu, Gen_AU
dc.contributor.authorKang, HGen_AU
dc.contributor.authorNishikido, Fen_AU
dc.contributor.authorYoshida, Een_AU
dc.contributor.authorChacon, Aen_AU
dc.contributor.authorSafavi-Naeini, Men_AU
dc.contributor.authorParodi, Ken_AU
dc.contributor.authorYamaya, Ten_AU
dc.date.accessioned2024-10-17T06:26:08Zen_AU
dc.date.available2024-10-17T06:26:08Zen_AU
dc.date.issued2020-06-12en_AU
dc.date.statistics2024-10-17en_AU
dc.description.abstractIn heavy-ion therapy, the stopping position of primary ions in tumours needs to be monitored for effective treatment and to prevent overdose exposure to normal tissues. Positron-emitting ion beams, such as 11C and 15O, have been suggested for range verification in heavy-ion therapy using in-beam positron emission tomography (PET) imaging, which offers the capability of visualizing the ion stopping position with a high signal-To-noise ratio. We have previously demonstrated the feasibility of in-beam PET imaging for the range verification of 11C and 15O ion beams and observed a slight shift between the beam stopping position and the dose peak position in simulations, depending on the initial beam energy spread. In this study, we focused on the experimental confirmation of the shift between the Bragg peak position and the position of the maximum detected positron-emitting fragments via a PET system for positron-emitting ion beams of 11C (210 MeV u-1) and 15O (312 MeV u-1) with momentum acceptances of 5% and 0.5%. For this purpose, we measured the depth doses and performed in-beam PET imaging using a polymethyl methacrylate (PMMA) phantom for both beams with different momentum acceptances. The shifts between the Bragg peak position and the PET peak position in an irradiated PMMA phantom for the 15O ion beams were 1.8 mm and 0.3 mm for momentum acceptances of 5% and 0.5%, respectively. The shifts between the positions of two peaks for the 11C ion beam were 2.1 mm and 0.1 mm for momentum acceptances of 5% and 0.5%, respectively. We observed larger shifts between the Bragg peak and the PET peak positions for a momentum acceptance of 5% for both beams, which is consistent with the simulation results reported in our previous study. The biological doses were also estimated from the calculated relative biological effectiveness (RBE) values using a modified microdosimetric kinetic model (mMKM) and Monte Carlo simulation. Beams with a momentum acceptance of 5% should be used with caution for therapeutic applications to avoid extra dose to normal tissues beyond the tumour when the dose distal fall-off is located beyond the treatment volume. © 2020 Institute of Physics and Engineering in Medicineen_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber125006en_AU
dc.identifier.citationMohammadi, A., Tashima, H., Iwao, Y., Takyu, S., Akamatsu, G., Kang, H. G., Nishikido, F., Yoshida, E., Chacon, A., Safavi-Naeini, M., Parodi, K., & Yamaya, T. (2020). Influence of momentum acceptance on range monitoring of 11C and 15O ion beams using in-beam PET. Physics in Medicine & Biology, 65(12), 125006. doi:10.1088/1361-6560/ab8059en_AU
dc.identifier.issn0031-9155en_AU
dc.identifier.issn1361-6560en_AU
dc.identifier.issue12en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.urihttp://dx.doi.org/10.1088/1361-6560/ab8059en_AU
dc.identifier.urihttps://doi.org/10.1088/1361-6560/ab8059en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15748en_AU
dc.identifier.volume65en_AU
dc.languageengen_AU
dc.language.isoenen_AU
dc.publisherIOP Publishingen_AU
dc.subjectCarbonen_AU
dc.subjectIon beamsen_AU
dc.subjectMonitoringen_AU
dc.subjectMomentum transferen_AU
dc.subjectTumor cellsen_AU
dc.subjectDepthen_AU
dc.subjectDosesen_AU
dc.subjectHeavy ionsen_AU
dc.titleInfluence of momentum acceptance on range monitoring of 11C and 15O ion beams using in-beam PETen_AU
dc.typeJournal Articleen_AU
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