The use of SAXS and SANS to assist the design of block copolymers for ophthalmic applications

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dc.contributor.authorSaricilar, Sen_AU
dc.contributor.authorDavis, TPen_AU
dc.contributor.authorStenzel, Men_AU
dc.contributor.authorBarner-Kowollik, Cen_AU
dc.contributor.authorKnott, RBen_AU
dc.date.accessioned2023-01-13T00:50:08Zen_AU
dc.date.available2023-01-13T00:50:08Zen_AU
dc.date.issued2005-11-27en_AU
dc.date.statistics2022-05-26en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC 539.7217/2en_AU
dc.description.abstractThe important properties of soft, extended-wear contact lenses include biocompatibility, oxygen permeability, wettability, material strength and stability. Significant overnight corneal swelling caused by low oxygen permeability limits the use of conventional hydrogels. The effect of molecular architecture on oxygen permeability is being investigated for a range of diblock copolymers based on monomers currently used in the contact lens industry. Diblock copolymers are synthesised via the controlled free radical polymerisation (RAFT) of 3-[tris(trimethyl silyoxy) silyl] propyl methacrylate (TRIS) with (i) methyl methacrylate (l\l|l\llA), and (ii) tert-butyl methacrylate (t-BuI\llA). The aim is to develop novel diblock copolymers with oxygen permeability (Dk) above 100 barrers in combination with superior hydration properties that will lead to materials suitable for extended-wear contact lenses. The molecular architecture of diblock copolymers has been determined using Small Angle X-ray and Neutron Scattering (SAXS and SANS), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM), and the results correlated with oxygen permeability and hydration effects. © The Authorsen_AU
dc.identifier.booktitleFinal Programme and Abstract Booken_AU
dc.identifier.citationSaricilar, S., Davis, T. P., Stenzel, M., Barner-Kowollik, B., & Knott, R. B. (2005). The use of SAXS and SANS to assist the design of block copolymers for ophthalmic applications. Paper presented at the Eighth International Conference on Neutron Scattering ICNS 2005: "Neutrons for structure and dynamics - a new era", Sydney Convention & Exhibition Centre, Sydney, Australia, 27 November-2 December 2005. In Final Programme and Abstract Book, (pp. 281).en_AU
dc.identifier.conferenceenddate2 December 2005en_AU
dc.identifier.conferencenameEighth International Conference on Neutron Scattering ICNS 2005: 'Neutrons for structure and dynamics - a new eraen_AU
dc.identifier.conferenceplaceSydney, Australiaen_AU
dc.identifier.conferencestartdate27 November 2005en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/14332en_AU
dc.language.isoenen_AU
dc.publisherThe Bragg Institute, Australian Nuclear Science and Technology Organisationen_AU
dc.subjectScatteringen_AU
dc.subjectCorneaen_AU
dc.subjectOxygenen_AU
dc.subjectCopolymersen_AU
dc.subjectPolymerizationen_AU
dc.subjectMicroscopyen_AU
dc.subjectHydrationen_AU
dc.subjectOphthalmologyen_AU
dc.titleThe use of SAXS and SANS to assist the design of block copolymers for ophthalmic applicationsen_AU
dc.typeConference Abstracten_AU
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