Labeled rhenium complexes: radiofluorination, α-MSH cyclization, and deuterium substitutions

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dc.contributor.authorKlenner, MAen_AU
dc.contributor.authorDarwish, TAen_AU
dc.contributor.authorFraser, BHen_AU
dc.contributor.authorMassi, Men_AU
dc.contributor.authorPascali, Gen_AU
dc.date.accessioned2021-09-13T22:20:41Zen_AU
dc.date.available2021-09-13T22:20:41Zen_AU
dc.date.issued2020-06-19en_AU
dc.date.statistics2021-09-07en_AU
dc.description.abstractWhile radiopharmaceuticals incorporating rhenium-188 or rhenium-186 radioisotopes have been well documented in the literature, the labeling of rhenium complexes with alternative isotopes has received comparatively less attention. Such rhenium complexes have demonstrated significant utility in imaging melanoma tumors via complexation with α-melanocyte-stimulating hormone (α-MSH) analogues conjugated with radiometals and radiohalogens, improving fluorine-18 incorporation into ligands which were otherwise unable to be synthesized and elucidating improved understandings of rhenium mechanisms and coordination sites through deuterium incorporation. This review highlights each of these rhenium-labeling cases and discusses the benefits derived therein, thus providing a useful resource for researchers intending to label unique rhenium complexes. © 2020 American Chemical Societyen_AU
dc.identifier.citationKlenner, M. A., Darwish, T., Fraser, B. H., Massi, M., & Pascali, G. (2020). Labeled rhenium complexes: radiofluorination, α-MSH cyclization, and deuterium substitutions. Organometallics, 39(13), 2334-2351. doi:10.1021/acs.organomet.0c00267en_AU
dc.identifier.issn1520-6041en_AU
dc.identifier.issue13en_AU
dc.identifier.journaltitleOrganometallicsen_AU
dc.identifier.pagination2334-2351en_AU
dc.identifier.urihttps://doi.org/10.1021/acs.organomet.0c00267en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/11683en_AU
dc.identifier.volume39en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectNeoplasmsen_AU
dc.subjectRheniumen_AU
dc.subjectPeptidesen_AU
dc.subjectProteinsen_AU
dc.subjectRodentsen_AU
dc.subjectDeuteriumen_AU
dc.titleLabeled rhenium complexes: radiofluorination, α-MSH cyclization, and deuterium substitutionsen_AU
dc.typeJournal Articleen_AU
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