Combined SRCT & FXCT – the next steps

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dc.contributor.authorHall, CJen_AU
dc.contributor.authorAcres, RGen_AU
dc.contributor.authorWinnett, Aen_AU
dc.contributor.authorWang, Fen_AU
dc.date.accessioned2025-02-13T01:12:15Zen_AU
dc.date.available2025-02-13T01:12:15Zen_AU
dc.date.issued2016-03-22en_AU
dc.date.statistics2025-02-06en_AU
dc.description.abstractOne of the goals in developing synchrotron radiation x-ray computed tomography (SRCT) for biomedical specimens, is allowing particular tissues and cell types to be marked in the images. This is equivalent to the staining in histology, which enables researchers to visualise and measure tissue structure and biochemical processes within the specimen. Some progress in this direction for SRCT is being made, using a variety of contrast agents that alter the natural x-ray attenuation of the marked tissue [1]. However there are limits to the usefulness of these attenuation altering techniques. Often high concentrations of potentially disruptive chemicals are required with reduced compatibility for in-vivo studies. Another image highlighting technique which might prove more sensitive is x-ray fluorescence imaging. In this case usually endogenous elemental markers are visualised. We would like to develop a lower resolution, but wider field of view means of three-dimensional (3-D) fluorescence imaging compatible with SRCT. We have previously proposed a technique in which x-ray fluorescence CT (FXCT) and SRCT data can be collected simultaneously [2]. This work resulted in proof of concept modelling, and a simple experiment test system. We show data here which demonstrate a two-dimensional (2-D) reconstruction of an iodine fluorescence map from a phantom. Measurements were performed with a fixed beam modulating mask using the Imaging and Medical beam line (IMBL) at the Australian Synchrotron. Fluorescence data was obtained during a CT scan using a single point detector, while transmission data was simultaneously collected using an area detector. A maximum likelihood expectation maximisation (MLEM) iterative algorithm was used to reconstruct the fluorescence map. We report on technique development and now believe compressive sensing (CS) imaging techniques suit SRCT and may overcome the issues encountered so far in combining SRCT and FXCT. © 2016 IOP Publishing Ltd and Sissa Medialab srl.en_AU
dc.identifier.articlenumberC03048en_AU
dc.identifier.citationHall, C., Acres, R. G., Winnett, A., & Wang, F. (2016). Combined SRCT & FXCT – the next steps. Paper presented to the Symposium on Multi-scale and Multi-dimensional Synchrotron Radiation Imaging Techniques and Applications (MMSRI-2015), 3-6 November 2015 , Shanghai, P.R. China. In Journal of Instrumentation, 11(03), C03048. doi:10.1088/1748-0221/11/03/C03048en_AU
dc.identifier.conferenceenddate2015-11-06en_AU
dc.identifier.conferencenameSymposium on Multi-scale and Multi-dimensional Synchrotron Radiation Imaging Techniques and Applications (MMSRI-2015)en_AU
dc.identifier.conferenceplaceShanghai, P.R. Chinaen_AU
dc.identifier.conferencestartdate2015-11-03en_AU
dc.identifier.issn1748-0221en_AU
dc.identifier.issue03en_AU
dc.identifier.journaltitleJournal of Instrumentationen_AU
dc.identifier.urihttps://doi.org/10.1088/1748-0221/11/03/c03048en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15977en_AU
dc.identifier.volume11en_AU
dc.language.isoenen_AU
dc.publisherIOP Publishingen_AU
dc.subjectSynchrotronsen_AU
dc.subjectTomographyen_AU
dc.subjectIodineen_AU
dc.subjectFluorescenceen_AU
dc.subjectAustraliaen_AU
dc.subjectImagesen_AU
dc.subjectIn vivoen_AU
dc.subjectAustralian organizationsen_AU
dc.subjectANSTOen_AU
dc.subjectBeamsen_AU
dc.titleCombined SRCT & FXCT – the next stepsen_AU
dc.typeConference Paperen_AU
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