Propagation-based phase-contrast CT of the breast demonstrates higher quality than conventional absorption-based CT even at lower radiation dose

Simple item page
dc.contributor.authorTaba, STen_AU
dc.contributor.authorArhatari, BDen_AU
dc.contributor.authorNesterets, YIen_AU
dc.contributor.authorGadomkar, Zen_AU
dc.contributor.authorMayo, SCen_AU
dc.contributor.authorThompson, Den_AU
dc.contributor.authorFox, Jen_AU
dc.contributor.authorKumar, Ben_AU
dc.contributor.authorProdanovic, Zen_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorMaksimenko, Aen_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorDimmock, MRen_AU
dc.contributor.authorPavlov, KMen_AU
dc.contributor.authorLockie, Den_AU
dc.contributor.authorGity, Men_AU
dc.contributor.authorPeele, AGen_AU
dc.contributor.authorQuiney, HMen_AU
dc.contributor.authorLewis, SJen_AU
dc.contributor.authorGureyev, TEen_AU
dc.contributor.authorBrennan, PCen_AU
dc.date.accessioned2023-12-19T01:24:38Zen_AU
dc.date.available2023-12-19T01:24:38Zen_AU
dc.date.issued2021-01en_AU
dc.date.statistics2023-04-27en_AU
dc.description.abstractRationale and Objectives Propagation-based phase-contrast CT (PB-CT) is an advanced X-ray imaging technology that exploits both refraction and absorption of the transmitted X-ray beam. This study was aimed at optimizing the experimental conditions of PB-CT for breast cancer imaging and examined its performance relative to conventional absorption-based CT (AB-CT) in terms of image quality and radiation dose. Materials and Methods Surgically excised breast mastectomy specimens (n = 12) were scanned using both PB-CT and AB-CT techniques under varying imaging conditions. To evaluate the radiological image quality, visual grading characteristics (VGC) analysis was used in which 11 breast specialist radiologists compared the overall image quality of PB-CT images with respect to the corresponding AB-CT images. The area under the VGC curve was calculated to measure the differences between PB-CT and AB-CT images. Results The highest radiological quality was obtained for PB-CT images using a 32 keV energy X-ray beam and by applying the Homogeneous Transport of Intensity Equation phase retrieval with the value of its parameter γ set to one-half of the theoretically optimal value for the given materials. Using these optimized conditions, the image quality of PB-CT images obtained at 4 mGy and 2 mGy mean glandular dose was significantly higher than AB-CT images at 4 mGy (AUCVGC = 0.901, p = 0.001 and AUCVGC = 0.819, p = 0.011, respectively). Conclusion PB-CT achieves a higher radiological image quality compared to AB-CT even at a considerably lower mean glandular dose. Successful translation of the PB-CT technique for breast cancer imaging can potentially result in improved breast cancer diagnosis. Crown Copyright © 2020 Published by Elsevier Inc. on behalf of The Association of University Radiologists.en_AU
dc.description.sponsorshipThis work was supported by National Health and Medical Research Council (NHMRC), Australia [grant number APP1138283]. This work was undertaken at the Imaging and Medical beamline of the Australian Synchrotron, part of ANSTO. The authors thank all patients for consenting to use the mastectomy samples in this study. The authors also acknowledge the assistance of staff at Monash Health BioBank, Australia.en_AU
dc.identifier.citationTaba, S. T., Arhatari, B. D., Nesterets, Y. I., Gadomkar, Z., Mayo, S. C., Thompson, D., Fox, J., Kumar, B., Prodanovic, Z., Hausermann, D., Maksimenko, A., Hall, C., Dimmock, M., Pavlov, K. M., Lockie, D., Gity, M., Peele, A., Quiney, H. M., Lewis, S., Gureyev, T. E., & Brennan, P. C. (2021). Propagation-based phase-contrast CT of the breast demonstrates higher quality than conventional absorption-based CT even at lower radiation dose. Academic Radiology, 28(1), e20-e26. doi:10.1016/j.acra.2020.01.009en_AU
dc.identifier.issn1076-6332en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleAcademic Radiologyen_AU
dc.identifier.paginatione20-e26en_AU
dc.identifier.urihttps://doi.org/10.1016/j.acra.2020.01.009en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15289en_AU
dc.identifier.volume28en_AU
dc.language.isoenen_AU
dc.publisherElsevier B. V.en_AU
dc.relation.urihttps://doi.org/10.1016/j.acra.2020.01.009en_AU
dc.subjectMammary glandsen_AU
dc.subjectRadiation dosesen_AU
dc.subjectContrast mediaen_AU
dc.subjectImagesen_AU
dc.subjectAbsorptionen_AU
dc.subjectCAT scanningen_AU
dc.titlePropagation-based phase-contrast CT of the breast demonstrates higher quality than conventional absorption-based CT even at lower radiation doseen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles