Synthesis of a new cage ligand, SarAr, and its complexation with selected transition metal ions for potential use in radioimaging

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dc.contributor.authorDi Bartolo, NMen_AU
dc.contributor.authorSargeson, AMen_AU
dc.contributor.authorDonlevy, TMen_AU
dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2024-06-06T02:14:22Zen_AU
dc.date.available2024-06-06T02:14:22Zen_AU
dc.date.issued2001-07-12en_AU
dc.date.statistics2024-05-24en_AU
dc.description.abstractA new hexaazamacrobicyclic cage ligand, 1-N-(4-aminobenzyl)-3,6,10,13,16,19-hexaazabicyclo[6.6.6]eicosane-1,8-diamine (SarAr) has been designed for conjugation to proteins. SarAr was synthesised and characterised by microanalyses, 1H NMR and electrospray mass spectrometry. The complexation of selected transition metal ions (Cu(II), Ni(II) and Co(II) at 10−6 M) by SarAr was complete within 30 min over pH 6 to 8. The [64Cu(SarAr)]2+ complex was investigated with a view to applications in radioimaging. The [64Cu(sar)]2+ complex was found to be stable in human plasma for at least 174 h and biodistribution studies in mice, showed that the [64Cu(SarAr)]2+complex was rapidly excreted through the renal system unlike the free 64Cu2+. Overall, the simple synthesis, ready complexation behaviour of SarAr, the kinetic inertness of the [Cu(SarAr)]2+ complex to dissociation of 64Cu and its facile elimination from mice make it an attractive prospect for use in nuclear medicine. © The Royal Society of Chemistry 2001en_AU
dc.identifier.citationDi Bartolo, N. M., Sargeson, A. M., Donlevy, T. M., & Smith, S. V. (2001). Synthesis of a new cage ligand, SarAr, and its complexation with selected transition metal ions for potential use in radioimaging. Journal of the Chemical Society, Dalton Transactions, (15), 2303-2309. doi:10.1039/B103242Aen_AU
dc.identifier.issn1472-7773en_AU
dc.identifier.issue15en_AU
dc.identifier.journaltitleJournal of the Chemical Society, Dalton Transactionsen_AU
dc.identifier.pagination2303-2309en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15626en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chemistryen_AU
dc.relation.urihttps://doi.org/10.1039/B103242Aen_AU
dc.subjectLigandsen_AU
dc.subjectMass spectroscopyen_AU
dc.subjectSynthesisen_AU
dc.subjectPlasmaen_AU
dc.subjectHumansen_AU
dc.subjectNuclear medicineen_AU
dc.subjectMiceen_AU
dc.subjectPolymersen_AU
dc.titleSynthesis of a new cage ligand, SarAr, and its complexation with selected transition metal ions for potential use in radioimagingen_AU
dc.typeJournal Articleen_AU
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