Bismuth-NSAIDs as colorectal cancer chemopreventives

Simple item page
dc.contributor.authorBrown, Ten_AU
dc.contributor.authorDillon, CTen_AU
dc.contributor.authorHolt, SAen_AU
dc.contributor.authorAndrews, Pen_AU
dc.contributor.authorPiantavigna, Sen_AU
dc.date.accessioned2023-12-07T21:42:02Zen_AU
dc.date.available2023-12-07T21:42:02Zen_AU
dc.date.issued2018-11-18en_AU
dc.date.statistics2023-05-25en_AU
dc.description.abstractTo date, epidemiological studies, animal studies and clinical trials have indicated the potential of non-steroidal anti-inflammatory drugs (NSAIDs) for the chemoprevention of colorectal cancer (CRC) [1]. Unfortunately, the use of NSAIDs for CRC chemoprevention is significantly limited due to the severe gastrointestinal (GI) side effects that have been associated with their long term use [1]. It is hypothesised that the coordination of NSAIDs to bismuth, a heavy metal with proven gastrointestinal sparing properties [2], may allow the use of NSAIDs as chemopreventives for CRC while also combating their associated GI side effects. The present study investigates the interactions of bismuth-coordinated NSAIDs (BiNSAIDs) with eukaryotic membrane mimics with the aim of establishing the possible uptake mechanisms of these compounds. This knowledge will be extended by investigating the behaviour of BiNSAIDs in more complex systems, including CRC cells and a CRC animal model. QCM-D studies involving biological membrane mimics composed of POPC or POPC/cholesterol demonstrated that BiNSAIDs and their parent NSAIDs interact with biological membranes [3]. Neutron reflectometry was also used to study the membrane interactions of BiNSAIDs and provided further evidence of the membrane interactions of BiNSAIDs, suggesting that passive diffusion is a likely method of uptake of these compounds [3]. These strength of these membrane interactions was an indicator of BiNSAID cytotoxicity against CRC cells.3 A CRC animal study has recently been completed with aspirin, which has promising preliminary results. In conclusion, the aforementioned studies continue to highlight the potential of BiNSAIDs as candidates for further investigations into their potential for the chemoprevention of CRC. © The Authorsen_AU
dc.identifier.citationBrown, T., Dillon, C., Holt, S., Andrews, P., & Piantavigna, S. (2018). Bismuth-NSAIDs as colorectal cancer chemopreventives. Paper presented to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018, AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234, Australia, Monday 19 November 2018 - Wednesday 21 November 2018, (pp. 13). Retrieved from https://events01.synchrotron.org.au/event/84/book-of-abstracts.pdf Presented at ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018, 19 - 21 November 2018, Sydney, Australia (pp. 13). Retrieved from https://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.identifier.conferenceenddate2018-11-21en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2018en_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate2018-11-19en_AU
dc.identifier.pagination13en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15268en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.relation.urihttps://events01.synchrotron.org.au/event/84/book-of-abstracts.pdfen_AU
dc.subjectEpidemiologyen_AU
dc.subjectAnimalsen_AU
dc.subjectClinical trialsen_AU
dc.subjectDrugsen_AU
dc.subjectHeavy metalsen_AU
dc.subjectBismuthen_AU
dc.subjectMembranesen_AU
dc.subjectNeutron reflectorsen_AU
dc.titleBismuth-NSAIDs as colorectal cancer chemopreventivesen_AU
dc.typeConference Abstracten_AU
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
book-of-abstracts.pdf
Size:
731.95 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Conference Publications