Kinetic small angle neutron scattering to study large biomolecular complexes

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dc.contributor.authorInoue, Ren_AU
dc.contributor.authorWood, Ken_AU
dc.contributor.authorSugiyama, Men_AU
dc.date.accessioned2021-10-26T21:38:09Zen_AU
dc.date.available2021-10-26T21:38:09Zen_AU
dc.date.issued2016-11-29en_AU
dc.date.statistics2021-10-11en_AU
dc.description.abstractProteins are the structural building blocks that make us up but also the functional molecules that drive us. Amazing advances over the last 60 years in structural biology mean we are now determining the 3D structure of over eight thousand proteins per year. Proteins rarely function as isolated entities however, and one of the next major challenges in structural biology is to examine the structure-function relationship in larger complexes made up of several individual proteins. Small angle scattering is particularly well suited to probe the space scale of large biomolecular complexes. The protein α-Crystallin makes up around a third of the structural proteins of mammalian eye lenses as well as displaying chaperone function. Here we examine the dynamical structure of α-Crystallin complexes by following exchange between the complexes using deuteration and small angle neutron scattering [1]. The work described is a result of collaborative work between all the authors listed below.en_AU
dc.identifier.citationInoue, R., Wood, K. & Sugiyama, M. (2016). Kinetic small angle neutron scattering to study large biomolecular complexes. Paper presented at 13th AINSE-ANBUG Neutron Scattering Symposium, Sydney, NSW, Australia, 29-30 November 2016.en_AU
dc.identifier.conferenceenddate30 November 2016en_AU
dc.identifier.conferencename13th AINSE-ANBUG Neutron Scattering Symposiumen_AU
dc.identifier.conferenceplaceSydney, NSW, Australiaen_AU
dc.identifier.conferencestartdate29 November 2016en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/12098en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineeringen_AU
dc.subjectProteinsen_AU
dc.subjectBiologyen_AU
dc.subjectMoleculesen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectDeuterationen_AU
dc.subjectEyesen_AU
dc.titleKinetic small angle neutron scattering to study large biomolecular complexesen_AU
dc.typeConference Abstracten_AU
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