Experimental investigation of the characteristics of radioactive beams for heavy ion therapy

Simple item page
dc.contributor.authorChacon, Aen_AU
dc.contributor.authorJames, Ben_AU
dc.contributor.authorTran, LTen_AU
dc.contributor.authorGuatelli, Sen_AU
dc.contributor.authorChartier, Len_AU
dc.contributor.authorProkopovich, DAen_AU
dc.contributor.authorFranklin, DRen_AU
dc.contributor.authorMohammadi, Aen_AU
dc.contributor.authorNishikido, Fen_AU
dc.contributor.authorIwao, Yen_AU
dc.contributor.authorAkamatsu, Gen_AU
dc.contributor.authorTakyu, Sen_AU
dc.contributor.authorTashima, Hen_AU
dc.contributor.authorYamaya, Ten_AU
dc.contributor.authorParodi, Ken_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.contributor.authorSafavi-Naeini, Men_AU
dc.date.accessioned2024-12-06T02:23:58Zen_AU
dc.date.available2024-12-06T02:23:58Zen_AU
dc.date.issued2020-07en_AU
dc.date.statistics2024-10-30en_AU
dc.descriptionDale Prokopvich is spelt incorrectly in the citation and on the website of the publisher. The correct spelling is Prokopovich.en_AU
dc.description.abstractPurpose This work has two related objectives. The first is to estimate the relative biological effectiveness of two radioactive heavy ion beams based on experimental measurements, and compare these to the relative biological effectiveness of corresponding stable isotopes to determine whether they are therapeutically equivalent. The second aim is to quantitatively compare the quality of images acquired postirradiation using an in‐beam whole‐body positron emission tomography scanner for range verification quality assurance. Methods The energy deposited by monoenergetic beams of C at 350 MeV/u, O at 250 MeV/u, C at 350 MeV/u, and O at 430 MeV/u was measured using a cruciform transmission ionization chamber in a water phantom at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. Dose‐mean lineal energy was measured at various depths along the path of each beam in a water phantom using a silicon‐on‐insulator mushroom microdosimeter. Using the modified microdosimetric kinetic model, the relative biological effectiveness at 10% survival fraction of the radioactive ion beams was evaluated and compared to that of the corresponding stable ions along the path of the beam. Finally, the postirradiation distributions of positron annihilations resulting from the decay of positron‐emitting nuclei were measured for each beam in a gelatin phantom using the in‐beam whole‐body positron emission tomography scanner at HIMAC. The depth of maximum positron‐annihilation density was compared with the depth of maximum dose deposition and the signal‐to‐background ratios were calculated and compared for images acquired over 5 and 20 min postirradiation of the phantom. Results In the entrance region, the was 1.2 ± 0.1 for both C and C beams, while for O and O it was 1.4 ± 0.1 and 1.3 ± 0.1, respectively. At the Bragg peak, the was 2.7 ± 0.4 for C and 2.9 ± 0.4 for C, while for O and O it was 2.7 ± 0.4 and 2.8 ± 0.4, respectively. In the tail region, could only be evaluated for carbon; the was 1.6 ± 0.2 and 1.5 ± 0.1 for C and C, respectively. Positron emission tomography images obtained from gelatin targets irradiated by radioactive ion beams exhibit markedly improved signal‐to‐background ratios compared to those obtained from targets irradiated by nonradioactive ion beams, with 5‐fold and 11‐fold increases in the ratios calculated for the O and C images compared with the values obtained for O and C, respectively. The difference between the depth of maximum dose and the depth of maximum positron annihilation density is 2.4 ± 0.8 mm for C, compared to −5.6 ± 0.8 mm for C and 0.9 ± 0.8 mm for O vs −6.6 ± 0.8 mm for O. Conclusions The values for C and O were found to be within the 95% confidence interval of the RBEs estimated for their corresponding stable isotopes across each of the regions in which it was evaluated. Furthermore, for a given dose, C and O beams produce much better quality images for range verification compared with C and O, in particular with regard to estimating the location of the Bragg peak. © 2024 American Association of Physicists in Medicine.en_AU
dc.description.sponsorshipThis research has been conducted with the support of the Australian government research training program scholarship. The authors acknowledge the scientific assistance of the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, at the Australian Nuclear Science and Technology Organisation (ANSTO). The authors acknowledge the long-term collaboration between the University of Wollongong’s Centre for Medical Radiation physics and Norway’s SINTEF research organization, where the silicon-on-insulator mushroom microdosimeters were fabricated.en_AU
dc.format.mediumPrint-Electronicen_AU
dc.identifier.citationChacon, A., James, B., Tran, L., Guatelli, S., Chartier, L., Prokopvich (sic), D., Franklin, D. R., Mohammadi, A., Nishikido, F., Iwao, Y., Akamatsu, G., Takyu, S., Tashima, H., Yamaya, T., Parodi, K., Rosenfeld, A., & Safavi-Naeini, M. (2020). Experimental investigation of the characteristics of radioactive beams for heavy ion therapy. Medical Physics, 47(7), 3123-3132. doi:10.1002/mp.14177en_AU
dc.identifier.issn0094-2405en_AU
dc.identifier.issn2473-4209en_AU
dc.identifier.issue7en_AU
dc.identifier.journaltitleMedical Physicsen_AU
dc.identifier.pagination3123-3132en_AU
dc.identifier.urihttps://doi.org/10.1002/mp.14177en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15804en_AU
dc.identifier.volume47en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherWileyen_AU
dc.subjectIonsen_AU
dc.subjectIon beamsen_AU
dc.subjectRadioactivityen_AU
dc.subjectBiologyen_AU
dc.subjectIsotopesen_AU
dc.subjectImagesen_AU
dc.subjectIonizationen_AU
dc.subjectMedicineen_AU
dc.subjectFragmentationen_AU
dc.subjectHeavy ionsen_AU
dc.subjectPositron computed tomographyen_AU
dc.titleExperimental investigation of the characteristics of radioactive beams for heavy ion therapyen_AU
dc.typeJournal Articleen_AU
dcterms.dateAccepted2020-03-26en_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.66 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles