Uptake of boronated monoclonal antibodies by melanoma cells visualised by track etch autoradiography and electron energy loss spectroscopy.

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dc.contributor.authorMoore, DEen_AU
dc.contributor.authorStretch, JRen_AU
dc.contributor.authorDawes, ALen_AU
dc.contributor.authorCockayne, DJHen_AU
dc.contributor.authorAllen, BJen_AU
dc.contributor.authorConstantine, Gen_AU
dc.date.accessioned2026-01-02T06:24:57Zen_AU
dc.date.available2026-01-02T06:24:57Zen_AU
dc.date.issued1992en_AU
dc.date.statistics2025-11-24en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 616.994/17en_AU
dc.description.abstractThe monoclonal antibody (MAb) NKI-C3 (Netherlands Cancer Institute) is a murine IgGl known to react with a formalin resistant antigen expressed by more than 95% of human melanomas. In principle, it can be used in the diagnosis of tissue sections for the presence of melanocytes, and with the appropriate level of boron labelling, this antibody could also be used for NCT of melanoma, provided its specificity is not impaired by the labelling process. The present study involves the use of two imaging techniques: first, α-track etch autoradiography to determine the specifiCity of the MAb after boronation, and second, electron energy loss spectroscopy to obtain information at the subcellular level concerning the localisation of the boron label. © Plenum Pressen_AU
dc.identifier.booktitleProgress in Neutron Capture Therapy for Canceren_AU
dc.identifier.citationMoore, D. E., Stretch, J. R., Dawes, A. L., Cockayne, D. J. H., Allen, B. J., & Constantine, G. (1992). Uptake of boronated monoclonal antibodies by melanoma cells visualised by track etch autoradiography and electron energy loss spectroscopy. Paper presented to the Fourth International Symposium on Neutron Capture Therapy for Cancer, December 4-7, 1990, Sydney, Australia. In B. J. Allen, D. E. Moore, & B. V. Harrington (Eds.), Progress in Neutron Capture Therapy for Cancer (pp. 335-338). New York, USA: Plenum Press.en_AU
dc.identifier.conferenceenddate1990-12-07en_AU
dc.identifier.conferencenameFourth International Symposium on Neutron Capture Therapy for Canceren_AU
dc.identifier.conferenceplaceSydney, Australiaen_AU
dc.identifier.conferencestartdate1990-12-04en_AU
dc.identifier.editorsB. J. Allen, D. E. Moore, & B. V. Harringtonen_AU
dc.identifier.isbn0306441047en_AU
dc.identifier.pagination335-338en_AU
dc.identifier.placeofpublicationNew York, USAen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16821en_AU
dc.language.isoenen_AU
dc.publisherPlenum Pressen_AU
dc.subjectBoronen_AU
dc.subjectAntibodiesen_AU
dc.subjectMelanomasen_AU
dc.subjectAutoradiographyen_AU
dc.subjectEnergy-loss spectroscopyen_AU
dc.subjectNetherlandsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectAchromatic Lesionsen_AU
dc.subjectCold neutronsen_AU
dc.subjectScatteringen_AU
dc.titleUptake of boronated monoclonal antibodies by melanoma cells visualised by track etch autoradiography and electron energy loss spectroscopy.en_AU
dc.typeConference Paperen_AU
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