Silver─gallium nano-amalgamated particles as a novel, biocompatible solution for antibacterial coatings

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dc.contributor.authorNguyen, TTen_AU
dc.contributor.authorZhang, PFen_AU
dc.contributor.authorBi, JWen_AU
dc.contributor.authorNguyen, NHen_AU
dc.contributor.authorDang, Yen_AU
dc.contributor.authorXu, ZNen_AU
dc.contributor.authorWang, Hen_AU
dc.contributor.authorNinan, Nen_AU
dc.contributor.authorBright, Ren_AU
dc.contributor.authorPham, Ten_AU
dc.contributor.authorNguyen, CKen_AU
dc.contributor.authorSabri, YMen_AU
dc.contributor.authorNguyen, MTen_AU
dc.contributor.authorVingsvivut, JPen_AU
dc.contributor.authorZhao, YPen_AU
dc.contributor.authorVasilev, Ken_AU
dc.contributor.authorTruong, VKen_AU
dc.date.accessioned2024-01-11T21:33:02Zen_AU
dc.date.available2024-01-11T21:33:02Zen_AU
dc.date.issued2023-11-05en_AU
dc.date.statistics2023-12-15en_AU
dc.description.abstractBacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, the alarming spread of antibiotic-resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity and genotoxicity of silver remain concern. To overcome these challenges, this proposes an easy-to-control and straightforward method to synthesize novel Silver─gallium (Ag─Ga) nano-amalgamated particles. Gallium liquid metal (GaLM) is used to facilitate the galvanic deposition of silver nanocrystals (Ag) on oxide layer. The GaLM not only serves as a carrier for silver through the galvanic replacement process, but also provides a controlled-release mechanism for silver, in this way improving biocompatibility, reducing inflammation, and stimulating bone growth. Notably, Ag─Ga suspensions can be conveniently deposited by spray-coating on a range of devices and material surfaces, effectively eliminating pathogenic bacteria with efficacy comparable to that of silver ions. In vivo studies in rat models affirm the antibacterial capabilities, especially against methicillin-resistant Staphylococcus aureus and Escherichia coli, when placed on implants such as titanium rods and magnesium discs. Furthermore, Ag─Ga promotes bone matrix formation and collagen growth without eliciting an inflammatory response, indicating a major promise for coatings on a wide variety of biomedical devices and materials. © 2023 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License.en_AU
dc.description.sponsorshipT.T.N., P.Z. and J.B. contributed equally to this work. K.V. thanks NHMRC for the Fellowship GNT1194466 and ARC for grant DP220103543. V.K.T. acknowledges the support from the Flinders Foundation Health Seed Grant. This work was supported by the National Natural Science Foundation of China (Grant No. 82072478 to Yunpeng Zhao), the Shandong Provincial Natural Science Foundation (Grant No. ZR2020YQ54, to Yunpeng Zhao), The Jinan clinical medicine and technological innovation plan (grant No. 202019195 to Hao Wang) and Shandong First Medical University Youth Science Foundation Incubation Project (grant no. 202201-063 to Hao Wang). The authors acknowledge the facilities, and the scientific and technical assistance of Microscopy Australia and the Australian National Fabrication Facility (ANFF) under the National Collaborative Research Infrastructure Strategy, at the South Australian Regional Facility, Flinders Microscopy and Microanalysis, Flinders University. The authors would also like to thank the RMIT Microscopy and Microanalysis Facility (RMMF). This research was undertaken on the IR microspectroscopy beamline at the Australian Synchrotron, part of ANSTO. The animal experiments were approved by the institutional review board of Shandong University. The authors would like to acknowledge the Translational Medicine Core Facility of Shandong University for consultation and instrument availability that supported this work. Open access publishing facilitated by Flinders University, as part of the Wiley - Flinders University agreement via the Council of Australian University Librarians.en_AU
dc.identifier.citationNguyen, T. T., Zhang, P., Bi, J., Nguyen, N. H., Dang, Y., Xu, Z., Wang, H., Ninan, N., Bright, R., Pham, T., Nguyen, C. K., Sabri, Y. M., Nguyen, M. T., Vongsvivut, J., Zhao, Y., Vasilev, K., & Truong, V. K. (2023). Silver─gallium nano‐amalgamated particles as a novel, biocompatible solution for antibacterial coatings. Advanced Functional Materials, 2310539. doi:10.1002/adfm.202310539en_AU
dc.identifier.issn1616-3028en_AU
dc.identifier.issue2310539en_AU
dc.identifier.journaltitleAdvanced Functional Materialsen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15328en_AU
dc.identifier.volumeEarly Viewen_AU
dc.language.isoenen_AU
dc.publisherWileyen_AU
dc.relation.urihttps://doi.org/10.1002/adfm.202310539en_AU
dc.subjectSilveren_AU
dc.subjectGalliumen_AU
dc.subjectWoundsen_AU
dc.subjectLiquid metalsen_AU
dc.subjectAntibioticsen_AU
dc.subjectNanocrystalsen_AU
dc.titleSilver─gallium nano-amalgamated particles as a novel, biocompatible solution for antibacterial coatingsen_AU
dc.typeJournal Articleen_AU
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