Opportunistic dose amplification for proton and carbon ion therapy via capture of internally generated thermal neutrons

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dc.contributor.authorSafavi-Naeini, Men_AU
dc.contributor.authorChacon, Aen_AU
dc.contributor.authorGuatelli, Sen_AU
dc.contributor.authorFranklin, DRen_AU
dc.contributor.authorBambery, KRen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.date.accessioned2025-01-10T03:16:30Zen_AU
dc.date.available2025-01-10T03:16:30Zen_AU
dc.date.issued2018-11-02en_AU
dc.date.statistics2024-10-16en_AU
dc.description.abstractThis paper presents Neutron Capture Enhanced Particle Therapy (NCEPT), a method for enhancing the radiation dose delivered to a tumour relative to surrounding healthy tissues during proton and carbon ion therapy by capturing thermal neutrons produced inside the treatment volume during irradiation. NCEPT utilises extant and in-development boron-10 and gadolinium-157-based drugs from the related field of neutron capture therapy. Using Monte Carlo simulations, we demonstrate that a typical proton or carbon ion therapy treatment plan generates an approximately uniform thermal neutron field within the target volume, centred around the beam path. The tissue concentrations of neutron capture agents required to obtain an arbitrary 10% increase in biological effective dose are estimated for realistic treatment plans, and compared to concentrations previously reported in the literature. We conclude that the proposed method is theoretically feasible, and can provide a worthwhile improvement in the dose delivered to the tumour relative to healthy tissue with readily achievable concentrations of neutron capture enhancement drugs. © 2024 The Authors published by Springer Nature Limited. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_AU
dc.description.sponsorshipThe authors would like to acknowledge the support of the Australian National Imaging Facility (NIF), University of Wollongong High Performance Cluster (HPC) and CMRP Centaur Cluster for supporting this work. This research has been conducted with the support of the Australian government research training program scholarship.en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber16257en_AU
dc.identifier.citationSafavi-Naeini, M., Chacon, A., Guatelli, S., Franklin, D. R., Bambery, K., Gregoire, M.-C., & Rosenfeld, A. (2018). Opportunistic dose amplification for proton and carbon ion therapy via capture of internally generated thermal neutrons. Scientific Reports, 8(1), 16257. doi:10.1038/s41598-018-34643-wen_AU
dc.identifier.issn2045-2322en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleScientific Reportsen_AU
dc.identifier.uridoi.org/10.1038/s41598-018-34643-wen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15897en_AU
dc.identifier.volume8en_AU
dc.languageEnglishen_AU
dc.language.isoenen_AU
dc.publisherSpringer Natureen_AU
dc.subjectDosesen_AU
dc.subjectProtonsen_AU
dc.subjectCarbon ionsen_AU
dc.subjectTherapyen_AU
dc.subjectThermal neutronsen_AU
dc.subjectNeutronsen_AU
dc.subjectGadoliniumen_AU
dc.subjectMonte Carlo Methoden_AU
dc.subjectSimulationen_AU
dc.subjectNeoplasmsen_AU
dc.subjectRadiation dose rangesen_AU
dc.subjectScatteringen_AU
dc.titleOpportunistic dose amplification for proton and carbon ion therapy via capture of internally generated thermal neutronsen_AU
dc.typeJournal Articleen_AU
dcterms.dateAccepted2018-10-22en_AU
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