Effect of x-ray energy on the radiological image quality in propagation-based phase-contrast computed tomography of the breast

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dc.contributor.authorWan, Sen_AU
dc.contributor.authorArhatari, BDen_AU
dc.contributor.authorNesterets, YIen_AU
dc.contributor.authorMayo, SCen_AU
dc.contributor.authorThompson, Den_AU
dc.contributor.authorFox, Jen_AU
dc.contributor.authorKumar, Ben_AU
dc.contributor.authorProdanovic, Zen_AU
dc.contributor.authorHäusermann, Den_AU
dc.contributor.authorMaksimenko, Aen_AU
dc.contributor.authorHall, CJen_AU
dc.contributor.authorDimmock, MRen_AU
dc.contributor.authorPavlov, KMen_AU
dc.contributor.authorLockie, Den_AU
dc.contributor.authorRickard, Men_AU
dc.contributor.authorGadomkar, Zen_AU
dc.contributor.authorAlaleh, Aen_AU
dc.contributor.authorVafa, Een_AU
dc.contributor.authorPeele, AGen_AU
dc.contributor.authorQuiney, HMen_AU
dc.contributor.authorLewis, SJen_AU
dc.contributor.authorGureyev, TEen_AU
dc.contributor.authorBrennan, PCen_AU
dc.contributor.authorTaba, STen_AU
dc.date.accessioned2023-12-19T01:24:31Zen_AU
dc.date.available2023-12-19T01:24:31Zen_AU
dc.date.issued2021-07-12en_AU
dc.date.statistics2023-04-18en_AU
dc.description.abstractPurpose: Breast cancer is the most common cancer in women in developing and developed countries and is responsible for 15% of women’s cancer deaths worldwide. Conventional absorption-based breast imaging techniques lack sufficient contrast for comprehensive diagnosis. Propagation-based phase-contrast computed tomography (PB-CT) is a developing technique that exploits a more contrast-sensitive property of x-rays: x-ray refraction. X-ray absorption, refraction, and contrast-to-noise in the corresponding images depend on the x-ray energy used, for the same/fixed radiation dose. The aim of this paper is to explore the relationship between x-ray energy and radiological image quality in PB-CT imaging. Approach: Thirty-nine mastectomy samples were scanned at the imaging and medical beamline at the Australian Synchrotron. Samples were scanned at various x-ray energies of 26, 28, 30, 32, 34, and 60 keV using a Hamamatsu Flat Panel detector at the same object-to-detector distance of 6 m and mean glandular dose of 4 mGy. A total of 132 image sets were produced for analysis. Seven observers rated PB-CT images against absorption-based CT (AB-CT) images of the same samples on a five-point scale. A visual grading characteristics (VGC) study was used to determine the difference in image quality. Results: PB-CT images produced at 28, 30, 32, and 34 keV x-ray energies demonstrated statistically significant higher image quality than reference AB-CT images. The optimum x-ray energy, 30 keV, displayed the largest area under the curve   (  AUCVGC  )   of 0.754 (p  =  0.009). This was followed by 32 keV (AUCVGC  =  0.731, p  ≤  0.001), 34 keV (AUCVGC  =  0.723, p  ≤  0.001), and 28 keV (AUCVGC  =  0.654, p  =  0.015). Conclusions: An optimum energy range (around 30 keV) in the PB-CT technique allows for higher image quality at a dose comparable to conventional mammographic techniques. This results in improved radiological image quality compared with conventional techniques, which may ultimately lead to higher diagnostic efficacy and a reduction in breast cancer mortalities.. © 2021 Society of Photo-Optical Instrumentation Engineers (SPIE).en_AU
dc.identifier.articlenumber052108en_AU
dc.identifier.citationWan, S., Arhatari, B. D., Nesterets, Y. I., Mayo, S. C., Thompson, D., Fox, J., Kumar, B., Prodanovic, Z., Hausermann, D., Maksimenko, A. S., Hall, C. J., Dimmock, M. R., Pavlov, K. M., Lockie, D., Rickard, M., Gandomkar, Z., Alaleh, A., Vafa, E., Peele, A. G., Quiney, H. M., Lewis, S. J., Gureyev, T. E., Brennan, P. C., & Taba, S. T. (2021). Effect of x-ray energy on the radiological image quality in propagation-based phase-contrast computed tomography of the breast. Journal of Medical Imaging, 8(5), 052108. doi:10.1117/1.JMI.8.5.052108en_AU
dc.identifier.issn2329-4310en_AU
dc.identifier.issue5en_AU
dc.identifier.journaltitleJournal of Medical Imagingen_AU
dc.identifier.urihttps://doi.org/10.1117/1.JMI.8.5.052108en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15288en_AU
dc.identifier.volume8en_AU
dc.language.isoenen_AU
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en_AU
dc.relation.urihttps://doi.org/10.1117/1.JMI.8.5.052108en_AU
dc.subjectContrast mediaen_AU
dc.subjectComputerized tomographyen_AU
dc.subjectMammary glandsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectDiagnosisen_AU
dc.subjectDiagnostic techniquesen_AU
dc.subjectAbsorptionen_AU
dc.subjectCAT scanningen_AU
dc.titleEffect of x-ray energy on the radiological image quality in propagation-based phase-contrast computed tomography of the breasten_AU
dc.typeJournal Articleen_AU
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