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Title: The synthesis and fluorescence profile of novel thalidomide analogues
Authors: Kampmann, SS
Skelton, BW
Yeoh, GC
Abraham, LJ
Lengkeek, NA
Stubbs, KA
Heath, CH
Stewart, SG
Keywords: Fluorescence
Issue Date: 21-Oct-2015
Publisher: Elsevier B.V.
Citation: Kampmann, S. S., Skelton, B. W., Yeoh, G. C., Abraham, L. J., Lengkeek, N. A., Stubbs, K. A.,Heath, C. H. & Stewart, S. G. (2015). The synthesis and fluorescence profile of novel thalidomide analogues. Tetrahedron, 71(42), 8140-8149. doi:10.1016/j.tet.2015.08.036
Abstract: Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes. © 2015 Elsevier Ltd.
Gov't Doc #: 8777
ISSN: 0040-4020
Appears in Collections:Journal Articles

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