The synthesis and fluorescence profile of novel thalidomide analogues

Kampmann, SS; Skelton, BW; Yeoh, GC; Abraham, LJ; Lengkeek, NA; Stubbs, KA; Heath, CH; Stewart, SG

The synthesis and fluorescence profile of novel thalidomide analogues

Date

2015-10-21

Authors

Publisher

Elsevier B.V.

Abstract

Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes. © 2015 Elsevier Ltd.

Keywords

Fluorescence, Probes, Triazoles, Drugs, Neoplasms, Lymphokines, Neoplasms

Citation

Kampmann, S. S., Skelton, B. W., Yeoh, G. C., Abraham, L. J., Lengkeek, N. A., Stubbs, K. A.,Heath, C. H. & Stewart, S. G. (2015). The synthesis and fluorescence profile of novel thalidomide analogues. Tetrahedron, 71(42), 8140-8149. doi:10.1016/j.tet.2015.08.036