National Deuteration Facility

Abstract

The Australian Nuclear Science and Technology Organisation’s (ANSTO) National Deuteration Facility (NDF) offers the facilities, staff and expertise to produce molecules where all or part of the molecular hydrogen is in the form of deuterium (2H or D). The facility produces deuterated proteins, biopolymers, nucleic acids and synthesised small organic molecules such as lipids, phospholipids, sugars, surfactants, aliphatic hydrocarbons and aromatic, heterocyclic compounds. Double and triple labelling of proteins with both deuterium and the stable isotopes carbon-13 and/or nitrogen-15, are also available. The NDF offers molecular deuteration using either in vivo biodeuteration or chemical deuteration techniques.