Journal Publications

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Browsing Journal Publications by Author "Abraham, LJ"

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    The synthesis and fluorescence profile of novel thalidomide analogues
    (Elsevier B.V., 2015-10-21) Kampmann, SS; Skelton, BW; Yeoh, GC; Abraham, LJ; Lengkeek, NA; Stubbs, KA; Heath, CH; Stewart, SG
    Herein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes. © 2015 Elsevier Ltd.