Browsing by Author "Ung, AT"

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    Microfluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon source
    (Akadémiai Kiadó Zrt, 2016-06-22) Perkins, G; Khatib, O; Peterson, MB; Kallinen, A; Pham, TQ; Ung, AT; Greguric, ID; Pascali, G
    Carbon dioxide chemistry is an area of continuing growth in recent times, due to socioeconomic and environmental reasons. Several methods have now been reported for obtaining N-methylation on primary and secondary amines directly from CO2. We have translated in two microfluidic setups (Slug Flow [SF] and Tube-in-Tube [TiT]) a ruthenium (Ru)-catalyzed process previously reported using a pressure vessel. Here, we demonstrate how the SF approach is more efficient but requires more input to reach a steady state, while the TiT system is less efficient but more tuneable.We have tested these processes on three model amines and two radiopharmaceutical precursors that are routinely used in 11C chemistry. The microfluidic processes tested are also potentially more efficient than the pressure vessel counterpart, in terms of amount of Ru catalyst needed (1% vs. 10%) and projected reaction completion time. © 2016 Akadémiai Kiadó Zrt.
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    Sulfur - fluorine bond in PET radiochemistry
    (BioMed Central Ltd, 2017-07-17) Pascali, G; Matesic, L; Zhang, B; King, AT; Robinson, AJ; Ung, AT; Fraser, BH
    The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications. © The Authors - Creative Commons Attribution 4.0