Browsing by Author "Mohammadi, NS"

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    Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing no-donor prodrugs activated by b-lactamase
    (Royal Society of Chemistry, 2013-01-01) Yepuri, NR; Barraud, N; Mohammadi, NS; Kardak, BG; Kjelleberg, S; Rice, SA; Kelso, MJ
    Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3[prime or minute]-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme [small beta]-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. © 2013, Royal Society of Chemistry