Browsing by Author "Li, D"
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- ItemDHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet(Elsevier, 2013-07-01) Yu, YH; Wu, YZ; Patch, C; Wu, ZX; Szabo, A; Li, D; Huang, XFLow levels of docosahexaenoic acid (DHA) have been linked to a number of mental illnesses such as memory loss, depression and schizophrenia. While supplementation of DHA is beneficial in improving memory and cognition, the influence of dietary fats on the neurotransmitters and receptors involved in cognitive function is still not known. The aim of this study was to investigate serotonin receptor (5-HT(1A) and 5-HT2A), cannabinoid receptor (CB1) and gamma-aminobutyric acid type A (GABA(A)) receptor binding densities in the brain of male rats fed a high-saturated-fat (HF) diet, as well as the effect of DHA supplementation on HF diet. Alterations of these receptors in the post-mortem rat brain were detected by [(3)H]-WAY-100635, [(3)H]-ketanserin, [(3)H]-CP-55,940 and [(3)H]-muscimol binding autoradiography, respectively. In the hippocampus, the 5-HT(1A), CB1 and GABA(A) receptor binding densities significantly increased in response to an HF diet, while in the hypothalamus, 5-HT(1A) and CB1 binding densities significantly increased in HF-fed rats. Importantly, DHA supplementation prevented the HF-induced increase of receptors binding density in the hippocampus and hypothalamus. Furthermore, DHA supplementation attenuated 5-HT2A receptor binding density in the caudate putamen, anterior cingulate cortex and medial mammillary nucleus, which was also increased in HF group. This study showed that an HF diet increased 5-HT(1A), 5-HT2A, CB1 and GABA(A) receptor binding densities in the brain regions involved in cognitive function and that dietary DHA can attenuate such alterations. These findings provide insight into the mechanism by which DHA supplementation ameliorates reduced cognitive function associated with an HF diet. © 2013 Elsevier Inc.
- ItemA high-temperature performing and near-zero energy loss lead-free ceramic capacitor(Royal Society of Chemistry, 2023-08-21) Li, D; Xu, D; Zhao, W; Avdeev, M; Jing, H; Guo, Y; Zhou, T; Liu, W; Wang, D; Zhou, DA pivotal obstacle of obtaining dielectric ceramics with large recoverable energy density (Wrec) and ultrahigh energy efficiency (η) desperately needs to be overcome for the development of advanced energy storage devices for high pulsed power systems, especially via an environment-friendly lead-free method. Here we report a series of lead-free dielectric bulk ceramics for high-temperature energy storage capacitors with near-zero energy loss. Confirmed by aberration-corrected scanning transmission electron microscopy and phase-field simulation, a judiciously designed heterostructure in which rhombohedral and tetragonal polar nanoregions are embedded in a cubic paraelectric matrix was constructed. The combination of the increased breakdown strength and the minimized polarization hysteresis, respectively, based on the heterostructure design and repeated rolling process, contributes to a large Wrec of 10.28 J cm−3 and a record-high η of 97.11%, superior to the reported lead-free bulk ceramics. Based on such structure-induced advantages, the wide-temperature stability (25–200 °C) and high performance (Wrec ∼ 6.35 ± 9.1% J cm−3, η ∼ 94.82% ± 3.4%) of the dielectric ceramics broaden their application in high temperature energy storage systems. This work conspicuously contributes to the development of the next generation high-temperature capacitors and suggests a new paradigm that may stimulate the development of higher-performance energy storage dielectrics. Facebook Twitter LinkedIn YouTube© Royal Society of Chemistry 2024
- ItemTeasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice(Oxford University Press, 2013-09-01) Yu, YH; Wu, YZ; Wu, ZX; Wang, HQ; Li, D; Huang, XFChronic inflammation is involved in the pathogenesis of obesity and type 2 diabetes. Recently teasaponin, an extract from tea, has been shown to have antiinflammatory effects. We examined the effect of teasaponin on obesity, inflammation, glucose metabolism, and central leptin sensitivity in obese mice fed a high-fat (HF) diet for 16 weeks. Intraperitoneal injections of teasaponin (10 mg/kg, daily) for 21 days significantly decreased the food intake and body weight of HF diet-induced obese mice. Teasaponin treatment also reduced the protein levels of proinflammatory cytokines (TNF-α, IL-6, and/or IL-1β) and nuclear factor-κB signaling (phosphorylated inhibitory-κB kinase and phosphorylated inhibitory-κBα) in adipose tissue and the liver. The antiinflammatory effects of teasaponin were associated with improved glycemic status in the treated animals, evidenced by improved glucose tolerance, homeostasis model assessment, and fasting plasma insulin. In the hypothalamus, teasaponin decreased both proinflammatory cytokines and inflammatory signaling in the mediobasal hypothalamus. Teasaponin treatment also enhanced the anorexigenic effect of central leptin administration, restored leptin phosphorylated signal transducer and activator of transcription-3 (p-STAT3) signaling in the arcuate nucleus, and increased hypothalamic expression of the anorexigenic peptide proopiomelanocortin. These results identify a potential novel application for teasaponin as an antiobesity and antiinflammatory agent. © 2013, Oxford University Press