Browsing by Author "Kallinen, A"

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    [18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic system
    (CSIRO Publishing, 2014-06-06) Matesic, L; Kallinen, A; Wyatt, NA; Pham, TQ; Greguric, I; Pascali, G
    The [18F]radiolabelling of the melanin-targeting positron-emission tomography radiotracer [18F]MEL050 was rapidly optimised using a commercial continuous-flow microfluidic system. The optimal [18F]fluorination incorporation conditions were then translated to production-scale experiments (35–150 GBq) suitable for preclinical imaging, complete with automated HPLC–solid phase extraction purification and formulation. [18F]MEL050 was obtained in 43 ± 10 % radiochemical yield in ~50 min. © 2015 CSIRO Publishing.
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    Microfluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon source
    (Akadémiai Kiadó Zrt, 2016-06-22) Perkins, G; Khatib, O; Peterson, MB; Kallinen, A; Pham, TQ; Ung, AT; Greguric, I; Pascali, G
    Carbon dioxide chemistry is an area of continuing growth in recent times, due to socioeconomic and environmental reasons. Several methods have now been reported for obtaining N-methylation on primary and secondary amines directly from CO2. We have translated in two microfluidic setups (Slug Flow [SF] and Tube-in-Tube [TiT]) a ruthenium (Ru)-catalyzed process previously reported using a pressure vessel. Here, we demonstrate how the SF approach is more efficient but requires more input to reach a steady state, while the TiT system is less efficient but more tuneable.We have tested these processes on three model amines and two radiopharmaceutical precursors that are routinely used in 11C chemistry. The microfluidic processes tested are also potentially more efficient than the pressure vessel counterpart, in terms of amount of Ru catalyst needed (1% vs. 10%) and projected reaction completion time. © 2016 Akadémiai Kiadó Zrt.