Browsing by Author "Huang, YH"

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    Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity
    (Wiley-V C H Verlag, 2013-03-18) Chan, LY; Zhang, VM; Huang, YH; Waters, NC; Bansal, PS; Craik, DJ; Daly, NL
    Gomesin is an 18-residue peptide originally isolated from the hemocytes of the Brazilian spider Acanthoscurria gomesiana. A broad spectrum of bioactivities have been attributed to gomesin, including in vivo and in vitro cytotoxicity against tumour cells, antimicrobial, antifungal, anti-Leishmania and antimalarial effects. Given the potential therapeutic applications of gomesin, it was of interest to determine if an engineered version with a cyclic backbone has improved stability and bioactivity. Cyclization has been shown to confer enhanced stability and activity to a range of bioactive peptides and, in the case of a cone snail venom peptide, confer oral activity in a pain model. The current study demonstrates that cyclization improves the in vitro stability of gomesin over a 24 hour time period and enhances cytotoxicity against a cancer cell line without being toxic to a noncancerous cell line. In addition, antimalarial activity is enhanced upon cyclization. These findings provide additional insight into the influences of backbone cyclization on the therapeutic potential of peptides. © 2013, Wiley-VCH Verlag.
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    Unlocking fast and reversible sodium intercalation in NASICON Na4MnV(PO4)3 by fluorine substitution
    (Elsevier, 2021-11) Hou, J; Hadouchi, M; Sui, L; Liu, J; Tang, M; Kan, WH; Avdeev, M; Zhong, G; Liao, YK; Lai, YH; Chu, YH; Lin, HJ; Chen, CT; Hu, ZW; Huang, YH; Ma, J
    The exploitation of high energy and high power densities cathode materials for sodium ion batteries is a challenge. Na-super-ionic-conductor (NASICON) Na4MnV(PO4)3 is one of promising high-performance and low-cost cathode materials, however, still suffers from not reaching the theoretical capacity, low rate capability, and poor cycling stability. In this work, we deploy a novel sodium-deficient NASICON fluorinated phosphate cathode material for sodium ion batteries which demonstrates, notably, high energy and high power densities concomitant with high sodium diffusion kinetics. The enhanced performance of this novel Na3.85⬜0.15MnV(PO3.95F0.05)3 cathode was evidenced by demonstrating a relatively high energy density of ∼380 Wh kg−1 at low rate with much improved rate capability compared to non-doped Na4MnV(PO4)3, and long cycling life over 2000 cycles at high current rates. The structural investigation during battery operation using in situ x-ray diffraction (XRD) reveals bi-phase mechanism with high structural reversibility. The combined XRD and 23Na nuclear magnetic resonance (NMR) analyses demonstrate that the sodium extraction/insertion from Na2 is faster than Na1 site. These findings open promising prospects for unlocking of high energy and high power densities of NASICON phosphate materials by fluorine substitution towards high-performance sodium ion batteries. © 2021 Elsevier B.V.