Browsing by Author "Huang, X"

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    Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity
    (Elsevier Science BV, 2006-12-15) Huang, XF; Zavitsanou, K; Huang, X; Yu, YH; Wang, HQ; Chen, F; Lawrence, AJ; Deng, C
    This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice. © 2006, Elsevier Ltd.
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    Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain
    (Elsevier Science BV, 2006-08-10) Huang, XF; Han, M; Huang, X; Zavitsanou, K; Deng, C
    This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. © 2006, Elsevier Ltd.