Browsing by Author "Deng, C"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity
    (Elsevier Science BV, 2006-12-15) Huang, XF; Zavitsanou, K; Huang, X; Yu, YH; Wang, HQ; Chen, F; Lawrence, AJ; Deng, C
    This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice. © 2006, Elsevier Ltd.
  • No Thumbnail Available
    Item
    Neuropeptide Y mRNA expression levels following chronic olanzapine, clozapine and haloperidol administration in rats
    (Elseiver, 2006-06-03) Huang, XF; Deng, C; Zavitsanou, K
    Using quantitative in situ hybridization, this study examined regional changes in rat brain mRNA levels encoding neuropeptide Y (NPY) following olanzapine, clozapine and haloperidol administration (1.2, 1.5 and 2.0 mg/kg, oral) for 36 days. The NPY mRNA expression levels and patterns were examined after the last drug administration at both time points enabling the measurement of immediate effect at 2 h and the effects after 48 h of drug administration. It was found that all these drugs had an immediate effect on NPY mRNA expression, while virtually all these changes normalized 48 h after the drug treatments. A similarity in altered NPY mRNA expression patterns was seen between the olanzapine and clozapine groups; however, haloperidol was very different. Olanzapine and clozapine administration decreased NPY mRNA levels in the nucleus accumbens, striatum and anterior cingulate cortex (from −60% to −77%, p < 0.05). Haloperidol decreased NPY mRNA expression in the amygdala and hippocampus (−69%, −64%, p < 0.05). In the lateral septal nucleus, NPY mRNA levels significantly decreased in the olanzapine group (−66%, p < 0.05), a trend toward a decrease was observed in the clozapine group, and no change was found in the haloperidol treated group. These results suggest that the different effects of atypical and typical antipsychotics on NPY systems may reflect the neural chemical mechanisms responsible for the differences between these drugs in their effects in treating positive and negative symptoms of schizophrenia. The immediate decrease of NPY mRNA levels suggests an immediate reduction of NPY biosynthesis in response to these drugs. © 2006, Elsevier Ltd.
  • No Thumbnail Available
    Item
    Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain
    (Elsevier Science BV, 2006-08-10) Huang, XF; Han, M; Huang, X; Zavitsanou, K; Deng, C
    This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. © 2006, Elsevier Ltd.