Non-rigid registration method for mouse whole body skeleton registration.

No Thumbnail Available
Journal Title
Journal ISSN
Volume Title
Society of Photo-optical Instrumentation Engineers (SPIE)
Micro-CT/PET imaging scanner provides a powerful tool to study tumor in small rodents in response to therapy. Accurate image registration is a necessary step to quantify the characteristics of images acquired in longitudinal studies. Small animal registration is challenging because of the very deformable body of the animal often resulting in different postures despite physical restraints. In this paper, we propose a non-rigid registration approach for the automatic registration of mouse whole body skeletons, which is based on our improved 3D shape context non-rigid registration method. The whole body skeleton registration approach has been tested on 21 pairs of mouse CT images with variations of individuals and time-instances. The experimental results demonstrated the stability and accuracy of the proposed method for automatic mouse whole body skeleton registration. © 2012, SPIE.
Positron computed tomography, Mice, Skeleton, Neoplasms, Restraints, Positioning
Xiao, D., Zahra, D., Bourgeat, P., Berghofer, P., Tamayo, A. O., Wimberley, C., Grégoire, M. C., & Salvado. O. (2010). Non-rigid registration method for mouse whole body skeleton registration. Paper presented to the Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 14th February 2010. Town and Country Resort and Convention Center: San Diego, California. In Proceedings of SPIE, 7626, 76261N. doi:10.1117/12.844067