Vascular injury in lung disease

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dc.contributor.authorTucker, ADen_AU
dc.contributor.authorWyatt, JHen_AU
dc.contributor.authorBarry, JMen_AU
dc.contributor.authorUndery, Den_AU
dc.date.accessioned2007-11-22T04:24:30Zen_AU
dc.date.accessioned2010-04-30T04:36:24Zen_AU
dc.date.available2007-11-22T04:24:30Zen_AU
dc.date.available2010-04-30T04:36:24Zen_AU
dc.date.issued1975en_AU
dc.description.abstractInhaled particulates which stimulate a 'delayed', cellular mode of alveolar clearance are excreted to the airways through lymphoid foci in the bronchial bifurcations. The anatomic relations and developing pathology of the tissues adjacent to these foci, including the divisions of accompanying arteries, were studied by serial sectioning and photo-micrographic modelling of rat lungs. The changes are typical of classic 'delayed' inflammatory reactions and, in the rat, the fully developed stage is characterised by fibrinoid necrosis involving all three layers of the arterial wall in a linear lesion across the leading edge of the flow divider. An hypothesis was developed to relate the injury to pulsatile forces. Recent published findings indicate that similarly placed lesions, with species-specific changes in development, are universal in both cerebral and extra-cranial arterial forks of man and animals. Possible associations of the microvascular changes with human atherosclerosis and their further significance in pulmonary and systemic effects arising from industrial and environmental contaminants are explored.en_AU
dc.identifier.citationTucker, A. D., Wyatt, J. H., Barry, J. M., & Undery, D. (1975). Vascular injury in lung disease (AAEC/E341). Lucas Heights, N.S.W.: Australian Atomic Energy Commission Research Establishment.en_AU
dc.identifier.govdoc557en_AU
dc.identifier.isbn0642997152en_AU
dc.identifier.otherAAEC-E-341en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/547en_AU
dc.language.isoen_auen_AU
dc.publisherAustralian Atomic Energy Commissionen_AU
dc.subjectVascular diseasesen_AU
dc.subjectArteriosclerosisen_AU
dc.subjectBronchien_AU
dc.subjectLungsen_AU
dc.titleVascular injury in lung diseaseen_AU
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